Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary

Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the t...

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Main Authors:	Samantha B. Kemp, Marina Pasca di Magliano, Howard C. Crawford
Format:	article
Language:	EN
Published:	Elsevier 2021
Subjects:	Diseases of the digestive system. Gastroenterology RC799-869
Online Access:	https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf
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spelling	oai:doaj.org-article:c6ea5886473b4e40acf34f6c756e6adf2021-11-12T04:38:59ZMyeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary2352-345X10.1016/j.jcmgh.2021.07.006https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352345X2100151Xhttps://doaj.org/toc/2352-345XPancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the tumor microenvironment inhibit cytotoxic T-cell responses promoting carcinogenesis. Immune checkpoint therapy has not been effective in PDA, most likely because of this robust immune suppression, making it critical to elucidate mechanisms behind this phenomenon. Here, we review myeloid cell infiltration and cellular crosstalk in PDA progression and highlight current therapeutic approaches to target myeloid cell-driven immune suppression.Samantha B. KempMarina Pasca di MaglianoHoward C. CrawfordElsevierarticleDiseases of the digestive system. GastroenterologyRC799-869ENCellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1531-1542 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
description	Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells. Myeloid cells in the tumor microenvironment inhibit cytotoxic T-cell responses promoting carcinogenesis. Immune checkpoint therapy has not been effective in PDA, most likely because of this robust immune suppression, making it critical to elucidate mechanisms behind this phenomenon. Here, we review myeloid cell infiltration and cellular crosstalk in PDA progression and highlight current therapeutic approaches to target myeloid cell-driven immune suppression.
format	article
author	Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford
author_facet	Samantha B. Kemp Marina Pasca di Magliano Howard C. Crawford
author_sort	Samantha B. Kemp
title	Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
title_short	Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
title_full	Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
title_fullStr	Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
title_full_unstemmed	Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary
title_sort	myeloid cell mediated immune suppression in pancreatic cancersummary
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c6ea5886473b4e40acf34f6c756e6adf
work_keys_str_mv	AT samanthabkemp myeloidcellmediatedimmunesuppressioninpancreaticcancersummary AT marinapascadimagliano myeloidcellmediatedimmunesuppressioninpancreaticcancersummary AT howardccrawford myeloidcellmediatedimmunesuppressioninpancreaticcancersummary
_version_	1718431257232146432

Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary

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