Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years

Abstract Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of infection. We conducted a longitudinal study to evaluate changes in clinical and microbiological characteristics as well as outcomes of sequence type (ST) 72 MRSA bacteremia. We review...

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Autores principales:	Eunmi Yang, Eunsil Kim, Hyemin Chung, Yun Woo Lee, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6ecf3acd543449f913db109298a09bc
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spelling	oai:doaj.org-article:c6ecf3acd543449f913db109298a09bc2021-12-02T17:06:32ZChanging characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years10.1038/s41598-021-95115-22045-2322https://doaj.org/article/c6ecf3acd543449f913db109298a09bc2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95115-2https://doaj.org/toc/2045-2322Abstract Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of infection. We conducted a longitudinal study to evaluate changes in clinical and microbiological characteristics as well as outcomes of sequence type (ST) 72 MRSA bacteremia. We reviewed adult patients enrolled in a prospective cohort with ST72 MRSA bacteremia from August 2008 to December 2018 at Asan Medical Center, Seoul, South Korea. Changes in clinical characteristics, outcomes, and microbiological characteristics of patients over time were evaluated. Generalized linear and linear regression models were used to evaluate changes. Of the 1,760 isolates, 915 (62%) were MRSA bacteremia and 292 (31.9%) were ST72 MRSA. During the study period, the relative risk (RR) of MRSA bacteremia decreased annually by 3.7%; however, among MRSA bacteremia, RR of ST72 MRSA increased annually by 8.5%. Vancomycin minimum inhibitory concentration (MIC) decreased over the study period. Metastatic infection, persistent bacteremia, and recurrence of bacteremia within 12 weeks decreased significantly. There were no significant changes in 30-d and 12-week mortality. Antibiotic susceptibility of ST72 MRSA was evaluated, and the resistance rate to erythromycin decreased significantly. ST72 MRSA incidence increased annually; its vancomycin MIC and erythromycin resistance rate decreased over the 11 years.Eunmi YangEunsil KimHyemin ChungYun Woo LeeSeongman BaeJiwon JungMin Jae KimYong Pil ChongSung-Han KimSang-Ho ChoiSang-Oh LeeYang Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eunmi Yang Eunsil Kim Hyemin Chung Yun Woo Lee Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sung-Han Kim Sang-Ho Choi Sang-Oh Lee Yang Soo Kim Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
description	Abstract Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of infection. We conducted a longitudinal study to evaluate changes in clinical and microbiological characteristics as well as outcomes of sequence type (ST) 72 MRSA bacteremia. We reviewed adult patients enrolled in a prospective cohort with ST72 MRSA bacteremia from August 2008 to December 2018 at Asan Medical Center, Seoul, South Korea. Changes in clinical characteristics, outcomes, and microbiological characteristics of patients over time were evaluated. Generalized linear and linear regression models were used to evaluate changes. Of the 1,760 isolates, 915 (62%) were MRSA bacteremia and 292 (31.9%) were ST72 MRSA. During the study period, the relative risk (RR) of MRSA bacteremia decreased annually by 3.7%; however, among MRSA bacteremia, RR of ST72 MRSA increased annually by 8.5%. Vancomycin minimum inhibitory concentration (MIC) decreased over the study period. Metastatic infection, persistent bacteremia, and recurrence of bacteremia within 12 weeks decreased significantly. There were no significant changes in 30-d and 12-week mortality. Antibiotic susceptibility of ST72 MRSA was evaluated, and the resistance rate to erythromycin decreased significantly. ST72 MRSA incidence increased annually; its vancomycin MIC and erythromycin resistance rate decreased over the 11 years.
format	article
author	Eunmi Yang Eunsil Kim Hyemin Chung Yun Woo Lee Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sung-Han Kim Sang-Ho Choi Sang-Oh Lee Yang Soo Kim
author_facet	Eunmi Yang Eunsil Kim Hyemin Chung Yun Woo Lee Seongman Bae Jiwon Jung Min Jae Kim Yong Pil Chong Sung-Han Kim Sang-Ho Choi Sang-Oh Lee Yang Soo Kim
author_sort	Eunmi Yang
title	Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
title_short	Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
title_full	Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
title_fullStr	Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
title_full_unstemmed	Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years
title_sort	changing characteristics of s. aureus bacteremia caused by pvl-negative, mrsa strain over 11 years
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6ecf3acd543449f913db109298a09bc
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Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years

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