The Significance of Autoantibodies in Juvenile Dermatomyositis

The Significance of Autoantibodies in Juvenile Dermatomyositis

Juvenile dermatomyositis is a chronic and rare autoimmune disorder classified into the spectrum of idiopathic inflammatory myopathies. Although this entity is mainly characterized by the presence of pathognomonic cutaneous lesions and proximal muscle weakness, the clinical manifestation can be highl...

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Autores principales: Dominika Kwiatkowska, Adam Reich
Formato: article
Lenguaje:EN
Publicado: Hindawi Limited 2021
Materias:
Medicine
R
Acceso en línea:https://doaj.org/article/c6ee315e713b4053b714a291d2b824f1
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spelling oai:doaj.org-article:c6ee315e713b4053b714a291d2b824f12021-11-29T00:56:37ZThe Significance of Autoantibodies in Juvenile Dermatomyositis2314-614110.1155/2021/5513544https://doaj.org/article/c6ee315e713b4053b714a291d2b824f12021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5513544https://doaj.org/toc/2314-6141Juvenile dermatomyositis is a chronic and rare autoimmune disorder classified into the spectrum of idiopathic inflammatory myopathies. Although this entity is mainly characterized by the presence of pathognomonic cutaneous lesions and proximal muscle weakness, the clinical manifestation can be highly heterogeneous; thus, diagnosis might be challenging. Current treatment recommendations for juvenile dermatomyositis, based mainly upon case series, include the use of corticosteroids, immunomodulatory, and immunosuppressive agents. Recently, several specific autoantibodies have been shown to be associated with distinct clinical phenotypes of classic dermatomyositis. There is a need to further evaluate their relevance in the formation of various clinical features. Furthermore, while providing more personalized treatment strategies, one should consider diversity of autoantibody-related subgroups of juvenile dermatomyositis.Dominika KwiatkowskaAdam ReichHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
spellingShingle Medicine
R
Dominika Kwiatkowska
Adam Reich
The Significance of Autoantibodies in Juvenile Dermatomyositis
description Juvenile dermatomyositis is a chronic and rare autoimmune disorder classified into the spectrum of idiopathic inflammatory myopathies. Although this entity is mainly characterized by the presence of pathognomonic cutaneous lesions and proximal muscle weakness, the clinical manifestation can be highly heterogeneous; thus, diagnosis might be challenging. Current treatment recommendations for juvenile dermatomyositis, based mainly upon case series, include the use of corticosteroids, immunomodulatory, and immunosuppressive agents. Recently, several specific autoantibodies have been shown to be associated with distinct clinical phenotypes of classic dermatomyositis. There is a need to further evaluate their relevance in the formation of various clinical features. Furthermore, while providing more personalized treatment strategies, one should consider diversity of autoantibody-related subgroups of juvenile dermatomyositis.
format article
author Dominika Kwiatkowska
Adam Reich
author_facet Dominika Kwiatkowska
Adam Reich
author_sort Dominika Kwiatkowska
title The Significance of Autoantibodies in Juvenile Dermatomyositis
title_short The Significance of Autoantibodies in Juvenile Dermatomyositis
title_full The Significance of Autoantibodies in Juvenile Dermatomyositis
title_fullStr The Significance of Autoantibodies in Juvenile Dermatomyositis
title_full_unstemmed The Significance of Autoantibodies in Juvenile Dermatomyositis
title_sort significance of autoantibodies in juvenile dermatomyositis
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/c6ee315e713b4053b714a291d2b824f1
work_keys_str_mv AT dominikakwiatkowska thesignificanceofautoantibodiesinjuveniledermatomyositis
AT adamreich thesignificanceofautoantibodiesinjuveniledermatomyositis
AT dominikakwiatkowska significanceofautoantibodiesinjuveniledermatomyositis
AT adamreich significanceofautoantibodiesinjuveniledermatomyositis
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