miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory

Abstract MicroRNAs (miRNAs) are important epigenetic regulators of mRNA translation implicated in long-lasting synaptic plasticity and long-term memory (LTM). Since recent findings demonstrated a role of epigenetic regulation of gene expression in early memory phases we investigated whether epigenet...

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Autores principales:	Julia Michely, Susanne Kraft, Uli Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6f0dfb8a154420fb6045ef8d1c7aeb4
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spelling	oai:doaj.org-article:c6f0dfb8a154420fb6045ef8d1c7aeb42021-12-02T11:52:35ZmiR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory10.1038/s41598-017-08486-w2045-2322https://doaj.org/article/c6f0dfb8a154420fb6045ef8d1c7aeb42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08486-whttps://doaj.org/toc/2045-2322Abstract MicroRNAs (miRNAs) are important epigenetic regulators of mRNA translation implicated in long-lasting synaptic plasticity and long-term memory (LTM). Since recent findings demonstrated a role of epigenetic regulation of gene expression in early memory phases we investigated whether epigenetic regulation by miRNAs also contributes to early memory phases. We used the olfactory associative learning paradigm in honeybees and addressed the contribution of miRNAs depending on the conditioning strength. We selected miR-12, miR-124, and miR-125 that have been implicated in processes of neuronal plasticity and analysed their contribution to non-associative and associative learning using miRNA inhibitors. Blocking miR-12, miR-124, or miR125 neither affects gustatory sensitivity nor habituation nor sensitization. Blocking the function of miR-12 and miR-124 during and shortly after 3-trial conditioning impairs different early memory phases. Although different, the function of miR-12 and miR-124 is also required for early phases of transient memory that is induced by 1-trial conditioning. Blocking miR-125 has no effect on early memory independent of the conditioning strength. These findings demonstrate that distinct miRNAs contribute to early phases of both, transient memories as well as long-lasting memories.Julia MichelySusanne KraftUli MüllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Michely Susanne Kraft Uli Müller miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
description	Abstract MicroRNAs (miRNAs) are important epigenetic regulators of mRNA translation implicated in long-lasting synaptic plasticity and long-term memory (LTM). Since recent findings demonstrated a role of epigenetic regulation of gene expression in early memory phases we investigated whether epigenetic regulation by miRNAs also contributes to early memory phases. We used the olfactory associative learning paradigm in honeybees and addressed the contribution of miRNAs depending on the conditioning strength. We selected miR-12, miR-124, and miR-125 that have been implicated in processes of neuronal plasticity and analysed their contribution to non-associative and associative learning using miRNA inhibitors. Blocking miR-12, miR-124, or miR125 neither affects gustatory sensitivity nor habituation nor sensitization. Blocking the function of miR-12 and miR-124 during and shortly after 3-trial conditioning impairs different early memory phases. Although different, the function of miR-12 and miR-124 is also required for early phases of transient memory that is induced by 1-trial conditioning. Blocking miR-125 has no effect on early memory independent of the conditioning strength. These findings demonstrate that distinct miRNAs contribute to early phases of both, transient memories as well as long-lasting memories.
format	article
author	Julia Michely Susanne Kraft Uli Müller
author_facet	Julia Michely Susanne Kraft Uli Müller
author_sort	Julia Michely
title	miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
title_short	miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
title_full	miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
title_fullStr	miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
title_full_unstemmed	miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory
title_sort	mir-12 and mir-124 contribute to defined early phases of long-lasting and transient memory
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c6f0dfb8a154420fb6045ef8d1c7aeb4
work_keys_str_mv	AT juliamichely mir12andmir124contributetodefinedearlyphasesoflonglastingandtransientmemory AT susannekraft mir12andmir124contributetodefinedearlyphasesoflonglastingandtransientmemory AT ulimuller mir12andmir124contributetodefinedearlyphasesoflonglastingandtransientmemory
_version_	1718395010036006912

miR-12 and miR-124 contribute to defined early phases of long-lasting and transient memory

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