Optimal management of sarcopenia
Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2010
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c6f421a3ab1a41c685150851a47e23e0 |
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| Sumario: | Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of sarcopenia, and thereby reduce the age-related decline and disability. This paper reviews (1) the mechanisms of sarcopenia, (2) the diagnosis of sarcopenia, and (3) the potential interventions for ­sarcopenia. Multiple factors appear to be involved in the development of sarcopenia including the loss of muscle mass and muscle fibers, increased inflammation, altered hormonal levels, poor ­nutritional status, and altered renin–angiotensin system. The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options. To date, ­pharmacological ­interventions have shown limited efficacy in counteracting the effects of sarcopenia. Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors; however, further randomized controlled trials are required. Resistance training remains the most effective intervention for sarcopenia; however, older people maybe unable or unwilling to embark on strenuous exercise training programs.Keywords: aged, muscle function, sarcopenia |
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