Optimal management of sarcopenia
Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older...
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Dove Medical Press
2010
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oai:doaj.org-article:c6f421a3ab1a41c685150851a47e23e02021-12-02T04:19:27ZOptimal management of sarcopenia1178-1998https://doaj.org/article/c6f421a3ab1a41c685150851a47e23e02010-08-01T00:00:00Zhttps://www.dovepress.com/optimal-management-of-sarcopenia-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of sarcopenia, and thereby reduce the age-related decline and disability. This paper reviews (1) the mechanisms of sarcopenia, (2) the diagnosis of sarcopenia, and (3) the potential interventions for ­sarcopenia. Multiple factors appear to be involved in the development of sarcopenia including the loss of muscle mass and muscle fibers, increased inflammation, altered hormonal levels, poor ­nutritional status, and altered renin–angiotensin system. The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options. To date, ­pharmacological ­interventions have shown limited efficacy in counteracting the effects of sarcopenia. Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors; however, further randomized controlled trials are required. Resistance training remains the most effective intervention for sarcopenia; however, older people maybe unable or unwilling to embark on strenuous exercise training programs.Keywords: aged, muscle function, sarcopeniaLouise A BurtonDeepa SumukadasDove Medical Pressarticlesarcopeniaagedphysical functionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 217-228 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
sarcopenia aged physical function Geriatrics RC952-954.6 |
| spellingShingle |
sarcopenia aged physical function Geriatrics RC952-954.6 Louise A Burton Deepa Sumukadas Optimal management of sarcopenia |
| description |
Louise A Burton, Deepa SumukadasAgeing and Health, Division of Medical Sciences, University of Dundee, Dundee, Scotland, United KingdomAbstract: Sarcopenia is the progressive generalized loss of skeletal muscle mass, strength, and function which occurs as a consequence of aging. With a growing older population, there has been great interest in developing approaches to counteract the effects of sarcopenia, and thereby reduce the age-related decline and disability. This paper reviews (1) the mechanisms of sarcopenia, (2) the diagnosis of sarcopenia, and (3) the potential interventions for ­sarcopenia. Multiple factors appear to be involved in the development of sarcopenia including the loss of muscle mass and muscle fibers, increased inflammation, altered hormonal levels, poor ­nutritional status, and altered renin–angiotensin system. The lack of diagnostic criteria to identify patients with sarcopenia hinders potential management options. To date, ­pharmacological ­interventions have shown limited efficacy in counteracting the effects of sarcopenia. Recent evidence has shown benefits with angiotensin-converting enzyme inhibitors; however, further randomized controlled trials are required. Resistance training remains the most effective intervention for sarcopenia; however, older people maybe unable or unwilling to embark on strenuous exercise training programs.Keywords: aged, muscle function, sarcopenia |
| format |
article |
| author |
Louise A Burton Deepa Sumukadas |
| author_facet |
Louise A Burton Deepa Sumukadas |
| author_sort |
Louise A Burton |
| title |
Optimal management of sarcopenia |
| title_short |
Optimal management of sarcopenia |
| title_full |
Optimal management of sarcopenia |
| title_fullStr |
Optimal management of sarcopenia |
| title_full_unstemmed |
Optimal management of sarcopenia |
| title_sort |
optimal management of sarcopenia |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/c6f421a3ab1a41c685150851a47e23e0 |
| work_keys_str_mv |
AT louiseaburton optimalmanagementofsarcopenia AT deepasumukadas optimalmanagementofsarcopenia |
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