Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression

Terminal uridylyltransferase 4/7 (TUT4/7) binds to Lin28 and modifies let-7 precursor (pre-let-7) to regulate cell differentiation and proliferation. Here the authors report the crystal structure of the N-terminal Lin28-interacting module of TUT4, showing a role of the N-terminal zinc finger domain...

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Autores principales:	Seisuke Yamashita, Takashi Nagaike, Kozo Tomita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6f94fb71b5b413e9eaa2957b95f7b49
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spelling	oai:doaj.org-article:c6f94fb71b5b413e9eaa2957b95f7b492021-12-02T14:38:38ZCrystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression10.1038/s41467-019-09966-52041-1723https://doaj.org/article/c6f94fb71b5b413e9eaa2957b95f7b492019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09966-5https://doaj.org/toc/2041-1723Terminal uridylyltransferase 4/7 (TUT4/7) binds to Lin28 and modifies let-7 precursor (pre-let-7) to regulate cell differentiation and proliferation. Here the authors report the crystal structure of the N-terminal Lin28-interacting module of TUT4, showing a role of the N-terminal zinc finger domain in stabilizing the Lin28:pre-let-7:TUT4 ternary complex.Seisuke YamashitaTakashi NagaikeKozo TomitaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seisuke Yamashita Takashi Nagaike Kozo Tomita Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
description	Terminal uridylyltransferase 4/7 (TUT4/7) binds to Lin28 and modifies let-7 precursor (pre-let-7) to regulate cell differentiation and proliferation. Here the authors report the crystal structure of the N-terminal Lin28-interacting module of TUT4, showing a role of the N-terminal zinc finger domain in stabilizing the Lin28:pre-let-7:TUT4 ternary complex.
format	article
author	Seisuke Yamashita Takashi Nagaike Kozo Tomita
author_facet	Seisuke Yamashita Takashi Nagaike Kozo Tomita
author_sort	Seisuke Yamashita
title	Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
title_short	Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
title_full	Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
title_fullStr	Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
title_full_unstemmed	Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
title_sort	crystal structure of the lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c6f94fb71b5b413e9eaa2957b95f7b49
work_keys_str_mv	AT seisukeyamashita crystalstructureofthelin28interactingmoduleofhumanterminaluridylyltransferasethatregulateslet7expression AT takashinagaike crystalstructureofthelin28interactingmoduleofhumanterminaluridylyltransferasethatregulateslet7expression AT kozotomita crystalstructureofthelin28interactingmoduleofhumanterminaluridylyltransferasethatregulateslet7expression
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Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression

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