Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content>

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content>

ABSTRACT During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance (DDT) mechanisms that can bypass lesion...

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Autores principales: Matan Arbel, Alex Bronstein, Soumitra Sau, Batia Liefshitz, Martin Kupiec
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
DNA repair
Elg1
Rad52
salvage pathway
Srs2
homologous recombination
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c6fb9d83f3524b178fcfaa153a1f91ba
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