Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa

Satoko Nakagawa, Akio Oishi, Ken Ogino, Yukiko Makiyama, Masafumi Kurimoto, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Purpose: To investigate the association between visual changes and retinal vessel attenuation...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nakagawa S, Oishi A, Ogino K, Makiyama Y, Kurimoto M, Yoshimura N
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://doaj.org/article/c6fb9e7aa49841efb7e9201109040b5c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c6fb9e7aa49841efb7e9201109040b5c
record_format dspace
spelling oai:doaj.org-article:c6fb9e7aa49841efb7e9201109040b5c2021-12-02T08:58:01ZAssociation of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa1177-5483https://doaj.org/article/c6fb9e7aa49841efb7e9201109040b5c2014-08-01T00:00:00Zhttp://www.dovepress.com/association-of-retinal-vessel-attenuation-with-visual-function-in-eyes-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Satoko Nakagawa, Akio Oishi, Ken Ogino, Yukiko Makiyama, Masafumi Kurimoto, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Purpose: To investigate the association between visual changes and retinal vessel attenuation in patients with retinitis pigmentosa (RP).Design: A retrospective, longitudinal, observational cohort study.Methods: We analyzed 45 eyes from 45 subjects who were followed-up for ≥3 years at our clinic. Using the computer-based Interactive Vessel Analysis program, central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were determined. Age- and sex-matched controls from normal subjects were selected from our archived fundus photograph library. Visual acuity, visual field area (Goldmann perimetry, V4e white test light), mean deviation (Humphrey perimetry, central 10-2 program), and central macular thickness (optical coherence tomography) were analyzed for correlations with CRAE and CRVE.Results: Both CRAE and CRVE were significantly decreased in RP eyes (94.9±13.5 µm and 155.6±20.0 µm, respectively) compared with control eyes (138.1±14.7 µm and 215.0±20.4 µm, respectively, both P<0.001). After 3 years of follow-up, visual field area was associated with both CRAE (r=0.584, P<0.01) and CRVE (r=0.500, P=0.008). A significant association was also observed between mean deviation and CRAE (r=0.298, P=0.047). In eyes with RP, a narrower vessel caliber at baseline was associated with a larger decline in visual acuity over the 3-year follow-up interval (CRAE: r=-0.344, P=0.021; CRVE: r=-0.314, P=0.035).Conclusion: Retinal vessel caliber is associated with some visual functions in patients with RP. Keywords: retinitis pigmentosa, retinal vascular caliber, central retinal artery equivalent, central retinal vein equivalentNakagawa SOishi AOgino KMakiyama YKurimoto MYoshimura NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1487-1493 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Nakagawa S
Oishi A
Ogino K
Makiyama Y
Kurimoto M
Yoshimura N
Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
description Satoko Nakagawa, Akio Oishi, Ken Ogino, Yukiko Makiyama, Masafumi Kurimoto, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Purpose: To investigate the association between visual changes and retinal vessel attenuation in patients with retinitis pigmentosa (RP).Design: A retrospective, longitudinal, observational cohort study.Methods: We analyzed 45 eyes from 45 subjects who were followed-up for ≥3 years at our clinic. Using the computer-based Interactive Vessel Analysis program, central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were determined. Age- and sex-matched controls from normal subjects were selected from our archived fundus photograph library. Visual acuity, visual field area (Goldmann perimetry, V4e white test light), mean deviation (Humphrey perimetry, central 10-2 program), and central macular thickness (optical coherence tomography) were analyzed for correlations with CRAE and CRVE.Results: Both CRAE and CRVE were significantly decreased in RP eyes (94.9±13.5 µm and 155.6±20.0 µm, respectively) compared with control eyes (138.1±14.7 µm and 215.0±20.4 µm, respectively, both P<0.001). After 3 years of follow-up, visual field area was associated with both CRAE (r=0.584, P<0.01) and CRVE (r=0.500, P=0.008). A significant association was also observed between mean deviation and CRAE (r=0.298, P=0.047). In eyes with RP, a narrower vessel caliber at baseline was associated with a larger decline in visual acuity over the 3-year follow-up interval (CRAE: r=-0.344, P=0.021; CRVE: r=-0.314, P=0.035).Conclusion: Retinal vessel caliber is associated with some visual functions in patients with RP. Keywords: retinitis pigmentosa, retinal vascular caliber, central retinal artery equivalent, central retinal vein equivalent
format article
author Nakagawa S
Oishi A
Ogino K
Makiyama Y
Kurimoto M
Yoshimura N
author_facet Nakagawa S
Oishi A
Ogino K
Makiyama Y
Kurimoto M
Yoshimura N
author_sort Nakagawa S
title Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
title_short Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
title_full Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
title_fullStr Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
title_full_unstemmed Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
title_sort association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/c6fb9e7aa49841efb7e9201109040b5c
work_keys_str_mv AT nakagawas associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
AT oishia associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
AT oginok associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
AT makiyamay associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
AT kurimotom associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
AT yoshimuran associationofretinalvesselattenuationwithvisualfunctionineyeswithretinitispigmentosa
_version_ 1718398330882490368