Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis

Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocytes triggers a fat-specific “cold-mimetic” thermogen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kazuki Tajima, Kenji Ikeda, Yuji Tanabe, Ella A. Thomson, Takeshi Yoneshiro, Yasuo Oguri, Marc D. Ferro, Ada S. Y. Poon, Shingo Kajimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6fe438eef6244abb2103d07bbb951d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c6fe438eef6244abb2103d07bbb951d4
record_format	dspace
spelling	oai:doaj.org-article:c6fe438eef6244abb2103d07bbb951d42021-12-02T17:33:12ZWireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis10.1038/s41467-020-15589-y2041-1723https://doaj.org/article/c6fe438eef6244abb2103d07bbb951d42020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15589-yhttps://doaj.org/toc/2041-1723Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocytes triggers a fat-specific “cold-mimetic” thermogenesis response protecting mice against diet-induced obesity.Kazuki TajimaKenji IkedaYuji TanabeElla A. ThomsonTakeshi YoneshiroYasuo OguriMarc D. FerroAda S. Y. PoonShingo KajimuraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuki Tajima Kenji Ikeda Yuji Tanabe Ella A. Thomson Takeshi Yoneshiro Yasuo Oguri Marc D. Ferro Ada S. Y. Poon Shingo Kajimura Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
description	Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocytes triggers a fat-specific “cold-mimetic” thermogenesis response protecting mice against diet-induced obesity.
format	article
author	Kazuki Tajima Kenji Ikeda Yuji Tanabe Ella A. Thomson Takeshi Yoneshiro Yasuo Oguri Marc D. Ferro Ada S. Y. Poon Shingo Kajimura
author_facet	Kazuki Tajima Kenji Ikeda Yuji Tanabe Ella A. Thomson Takeshi Yoneshiro Yasuo Oguri Marc D. Ferro Ada S. Y. Poon Shingo Kajimura
author_sort	Kazuki Tajima
title	Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
title_short	Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
title_full	Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
title_fullStr	Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
title_full_unstemmed	Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
title_sort	wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c6fe438eef6244abb2103d07bbb951d4
work_keys_str_mv	AT kazukitajima wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT kenjiikeda wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT yujitanabe wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT ellaathomson wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT takeshiyoneshiro wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT yasuooguri wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT marcdferro wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT adasypoon wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis AT shingokajimura wirelessoptogeneticsprotectsagainstobesityviastimulationofnoncanonicalfatthermogenesis
_version_	1718380026313834496

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis

Ejemplares similares