Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit

Abstract Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Pati...

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Autores principales:	Ayham Daher, Paul Balfanz, Maria Aetou, Bojan Hartmann, Dirk Müller-Wieland, Tobias Müller, Nikolaus Marx, Michael Dreher, Christian G. Cornelissen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6feaf6aa837421ab757f11bf9e3b372
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spelling	oai:doaj.org-article:c6feaf6aa837421ab757f11bf9e3b3722021-12-02T10:48:31ZClinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit10.1038/s41598-021-81444-92045-2322https://doaj.org/article/c6feaf6aa837421ab757f11bf9e3b3722021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81444-9https://doaj.org/toc/2045-2322Abstract Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Patients without ARDS but in need of supplementary oxygen have received much less attention. This study describes the diagnosis, symptoms, treatment and outcomes of hospitalized patients with COVID-19 needing oxygen support during their stay on regular ward. All 133 patients admitted to the RWTH Aachen university hospital with the diagnosis of COVID-19 were included in an observational registry. Clinical data sets were extracted from the hospital information system. This analysis includes all 57 patients requiring supplemental oxygen not admitted to the ICU. 57 patients needing supplemental oxygen and being treated outside the ICU were analyzed. Patients exhibited the typical set of symptoms for COVID-19. Of note, hypoxic patients mostly did not suffer from clinically relevant dyspnea despite oxygen saturations below 92%. Patients had fever for 7 [2–11] days and needed supplemental oxygen for 8 [5–13] days resulting in an overall hospitalization time of 12 [7–20] days. In addition, patients had persisting systemic inflammation with CRP levels remaining elevated until discharge or death. This description of COVID-19 patients requiring oxygen therapy should be taken into account when planning treatment capacity. Patients on oxygen need long-term inpatient care.Ayham DaherPaul BalfanzMaria AetouBojan HartmannDirk Müller-WielandTobias MüllerNikolaus MarxMichael DreherChristian G. CornelissenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayham Daher Paul Balfanz Maria Aetou Bojan Hartmann Dirk Müller-Wieland Tobias Müller Nikolaus Marx Michael Dreher Christian G. Cornelissen Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
description	Abstract Patients suffering from CVOID-19 mostly experience a benign course of the disease. Approximately 14% of SARS-CoV2 infected patients are admitted to a hospital. Cohorts exhibiting severe lung failure in the form of acute respiratory distress syndrome (ARDS) have been well characterized. Patients without ARDS but in need of supplementary oxygen have received much less attention. This study describes the diagnosis, symptoms, treatment and outcomes of hospitalized patients with COVID-19 needing oxygen support during their stay on regular ward. All 133 patients admitted to the RWTH Aachen university hospital with the diagnosis of COVID-19 were included in an observational registry. Clinical data sets were extracted from the hospital information system. This analysis includes all 57 patients requiring supplemental oxygen not admitted to the ICU. 57 patients needing supplemental oxygen and being treated outside the ICU were analyzed. Patients exhibited the typical set of symptoms for COVID-19. Of note, hypoxic patients mostly did not suffer from clinically relevant dyspnea despite oxygen saturations below 92%. Patients had fever for 7 [2–11] days and needed supplemental oxygen for 8 [5–13] days resulting in an overall hospitalization time of 12 [7–20] days. In addition, patients had persisting systemic inflammation with CRP levels remaining elevated until discharge or death. This description of COVID-19 patients requiring oxygen therapy should be taken into account when planning treatment capacity. Patients on oxygen need long-term inpatient care.
format	article
author	Ayham Daher Paul Balfanz Maria Aetou Bojan Hartmann Dirk Müller-Wieland Tobias Müller Nikolaus Marx Michael Dreher Christian G. Cornelissen
author_facet	Ayham Daher Paul Balfanz Maria Aetou Bojan Hartmann Dirk Müller-Wieland Tobias Müller Nikolaus Marx Michael Dreher Christian G. Cornelissen
author_sort	Ayham Daher
title	Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_short	Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_full	Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_fullStr	Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_full_unstemmed	Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit
title_sort	clinical course of covid-19 patients needing supplemental oxygen outside the intensive care unit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6feaf6aa837421ab757f11bf9e3b372
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Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit

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