IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST

Searching for new chemotherapy strategies for cancer treatment, numerous traces of antitumor activity have been reported from different species of seaweeds extracts. This study is carried out an evaluation of the antitumor activity with methanolic extract of six species of seaweeds collected in the...

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Autores principales:	Sandra P. OSPINA G., Juan B. LÓPEZ O., María E. MÁRQUEZ F.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	biological activity citotoxity cell cycle seaweeds methanolic extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/c6fed28be0714bfd9eedd16bbd511cec
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spelling	oai:doaj.org-article:c6fed28be0714bfd9eedd16bbd511cec2021-11-19T04:20:45ZIN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST0121-40042145-2660https://doaj.org/article/c6fed28be0714bfd9eedd16bbd511cec2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/617https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Searching for new chemotherapy strategies for cancer treatment, numerous traces of antitumor activity have been reported from different species of seaweeds extracts. This study is carried out an evaluation of the antitumor activity with methanolic extract of six species of seaweeds collected in the colombian Caribbean sea, a cytotoxic test, an evaluation about the effect in the cell cycle line HT29 and a selective test in phytohemaglutinine-stimulated peripheral human blood-derived T-lymphocytes are done. All methanolic extracts showed antimitotic effect in the cell system with a wide spectrum of blockage on the mitotic phase from early prometaphase to late anaphase. None of the extracts tested produced an effect on chromosome morphology. This is the first report that demonstrates that the cytotoxic effect of seaweed methanolic extracts act by mitotic blocking, and suggest that methanolic extracts from Colombian seaweeds contains bioactive substances with potential pharmacological use in cancer chemotherapy and cytogenetic assays. Further studies on the usefulness of such substances as cell cycle blocking agents are in process. Sandra P. OSPINA G.Juan B. LÓPEZ O.María E. MÁRQUEZ F.Universidad de Antioquiaarticlebiological activitycitotoxitycell cycleseaweedsmethanolic extract.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological activity citotoxity cell cycle seaweeds methanolic extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	biological activity citotoxity cell cycle seaweeds methanolic extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Sandra P. OSPINA G. Juan B. LÓPEZ O. María E. MÁRQUEZ F. IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
description	Searching for new chemotherapy strategies for cancer treatment, numerous traces of antitumor activity have been reported from different species of seaweeds extracts. This study is carried out an evaluation of the antitumor activity with methanolic extract of six species of seaweeds collected in the colombian Caribbean sea, a cytotoxic test, an evaluation about the effect in the cell cycle line HT29 and a selective test in phytohemaglutinine-stimulated peripheral human blood-derived T-lymphocytes are done. All methanolic extracts showed antimitotic effect in the cell system with a wide spectrum of blockage on the mitotic phase from early prometaphase to late anaphase. None of the extracts tested produced an effect on chromosome morphology. This is the first report that demonstrates that the cytotoxic effect of seaweed methanolic extracts act by mitotic blocking, and suggest that methanolic extracts from Colombian seaweeds contains bioactive substances with potential pharmacological use in cancer chemotherapy and cytogenetic assays. Further studies on the usefulness of such substances as cell cycle blocking agents are in process.
format	article
author	Sandra P. OSPINA G. Juan B. LÓPEZ O. María E. MÁRQUEZ F.
author_facet	Sandra P. OSPINA G. Juan B. LÓPEZ O. María E. MÁRQUEZ F.
author_sort	Sandra P. OSPINA G.
title	IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
title_short	IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
title_full	IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
title_fullStr	IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
title_full_unstemmed	IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST
title_sort	in <i>vitro</i> antimitotic effect of methanolic extracts of seaweeds species from the colombian caribbean cost
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/c6fed28be0714bfd9eedd16bbd511cec
work_keys_str_mv	AT sandrapospinag inivitroiantimitoticeffectofmethanolicextractsofseaweedsspeciesfromthecolombiancaribbeancost AT juanblopezo inivitroiantimitoticeffectofmethanolicextractsofseaweedsspeciesfromthecolombiancaribbeancost AT mariaemarquezf inivitroiantimitoticeffectofmethanolicextractsofseaweedsspeciesfromthecolombiancaribbeancost
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IN <I>VITRO</I> ANTIMITOTIC EFFECT OF METHANOLIC EXTRACTS OF SEAWEEDS SPECIES FROM THE COLOMBIAN CARIBBEAN COST

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