A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.

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Detalles Bibliográficos
Autores principales: Ya Zhang, Liang Huang, Haiqing Fu, Owen K. Smith, Chii Mei Lin, Koichi Utani, Mishal Rao, William C. Reinhold, Christophe E. Redon, Michael Ryan, RyangGuk Kim, Yang You, Harlington Hanna, Yves Boisclair, Qiaoming Long, Mirit I. Aladjem
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/c6ff6c1a7efd4a8fa9a131eacd84cee4
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Descripción
Sumario:Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.

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