A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells
Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.
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Nature Portfolio
2016
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oai:doaj.org-article:c6ff6c1a7efd4a8fa9a131eacd84cee42021-12-02T16:50:55ZA replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells10.1038/ncomms117482041-1723https://doaj.org/article/c6ff6c1a7efd4a8fa9a131eacd84cee42016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11748https://doaj.org/toc/2041-1723Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.Ya ZhangLiang HuangHaiqing FuOwen K. SmithChii Mei LinKoichi UtaniMishal RaoWilliam C. ReinholdChristophe E. RedonMichael RyanRyangGuk KimYang YouHarlington HannaYves BoisclairQiaoming LongMirit I. AladjemNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ya Zhang Liang Huang Haiqing Fu Owen K. Smith Chii Mei Lin Koichi Utani Mishal Rao William C. Reinhold Christophe E. Redon Michael Ryan RyangGuk Kim Yang You Harlington Hanna Yves Boisclair Qiaoming Long Mirit I. Aladjem A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| description |
Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. |
| format |
article |
| author |
Ya Zhang Liang Huang Haiqing Fu Owen K. Smith Chii Mei Lin Koichi Utani Mishal Rao William C. Reinhold Christophe E. Redon Michael Ryan RyangGuk Kim Yang You Harlington Hanna Yves Boisclair Qiaoming Long Mirit I. Aladjem |
| author_facet |
Ya Zhang Liang Huang Haiqing Fu Owen K. Smith Chii Mei Lin Koichi Utani Mishal Rao William C. Reinhold Christophe E. Redon Michael Ryan RyangGuk Kim Yang You Harlington Hanna Yves Boisclair Qiaoming Long Mirit I. Aladjem |
| author_sort |
Ya Zhang |
| title |
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| title_short |
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| title_full |
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| title_fullStr |
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| title_full_unstemmed |
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells |
| title_sort |
replicator-specific binding protein essential for site-specific initiation of dna replication in mammalian cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/c6ff6c1a7efd4a8fa9a131eacd84cee4 |
| work_keys_str_mv |
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