High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites...

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Autores principales:	Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Simon M. G. Braun, Nicole Francis, Rabih Murr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c700bba4738648ac97b97852cfa493cc
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spelling	oai:doaj.org-article:c700bba4738648ac97b97852cfa493cc2021-12-02T14:58:13ZHigh throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites10.1038/s41467-021-23630-x2041-1723https://doaj.org/article/c700bba4738648ac97b97852cfa493cc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23630-xhttps://doaj.org/toc/2041-1723The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.Ludovica VanzanHadrien SoldatiVictor YthierSantosh AnandSimon M. G. BraunNicole FrancisRabih MurrNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
description	The functional relevance of epigenetic modifications on transcription regulation has been an important question since their discovery. Here, the authors investigate the effect of DNA methylation on Pioneer Transcription Factor (PF) binding and distinguish between PFs that protect their binding sites from methylation and those that bind to methylated DNA and induce DNA demethylation.
format	article
author	Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr
author_facet	Ludovica Vanzan Hadrien Soldati Victor Ythier Santosh Anand Simon M. G. Braun Nicole Francis Rabih Murr
author_sort	Ludovica Vanzan
title	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_short	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_full	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_fullStr	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_full_unstemmed	High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
title_sort	high throughput screening identifies sox2 as a super pioneer factor that inhibits dna methylation maintenance at its binding sites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c700bba4738648ac97b97852cfa493cc
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High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites

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