Stability of synchronization clusters and seizurability in temporal lobe epilepsy.

<h4>Purpose</h4>Identification of critical areas in presurgical evaluations of patients with temporal lobe epilepsy is the most important step prior to resection. According to the "epileptic focus model", localization of seizure onset zones is the main task to be accomplished....

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Autores principales:	Agostina Palmigiano, Jesús Pastor, Rafael García de Sola, Guillermo J Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c701d6dc7de848ee9f67fc653f80ab56
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spelling	oai:doaj.org-article:c701d6dc7de848ee9f67fc653f80ab562021-11-18T07:11:28ZStability of synchronization clusters and seizurability in temporal lobe epilepsy.1932-620310.1371/journal.pone.0041799https://doaj.org/article/c701d6dc7de848ee9f67fc653f80ab562012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22844524/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>Identification of critical areas in presurgical evaluations of patients with temporal lobe epilepsy is the most important step prior to resection. According to the "epileptic focus model", localization of seizure onset zones is the main task to be accomplished. Nevertheless, a significant minority of epileptic patients continue to experience seizures after surgery (even when the focus is correctly located), an observation that is difficult to explain under this approach. However, if attention is shifted from a specific cortical location toward the network properties themselves, then the epileptic network model does allow us to explain unsuccessful surgical outcomes.<h4>Methods</h4>The intraoperative electrocorticography records of 20 patients with temporal lobe epilepsy were analyzed in search of interictal synchronization clusters. Synchronization was analyzed, and the stability of highly synchronized areas was quantified. Surrogate data were constructed and used to statistically validate the results. Our results show the existence of highly localized and stable synchronization areas in both the lateral and the mesial areas of the temporal lobe ipsilateral to the clinical seizures. Synchronization areas seem to play a central role in the capacity of the epileptic network to generate clinical seizures. Resection of stable synchronization areas is associated with elimination of seizures; nonresection of synchronization clusters is associated with the persistence of seizures after surgery.<h4>Discussion</h4>We suggest that synchronization clusters and their stability play a central role in the epileptic network, favoring seizure onset and propagation. We further speculate that the stability distribution of these synchronization areas would differentiate normal from pathologic cases.Agostina PalmigianoJesús PastorRafael García de SolaGuillermo J OrtegaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41799 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agostina Palmigiano Jesús Pastor Rafael García de Sola Guillermo J Ortega Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
description	<h4>Purpose</h4>Identification of critical areas in presurgical evaluations of patients with temporal lobe epilepsy is the most important step prior to resection. According to the "epileptic focus model", localization of seizure onset zones is the main task to be accomplished. Nevertheless, a significant minority of epileptic patients continue to experience seizures after surgery (even when the focus is correctly located), an observation that is difficult to explain under this approach. However, if attention is shifted from a specific cortical location toward the network properties themselves, then the epileptic network model does allow us to explain unsuccessful surgical outcomes.<h4>Methods</h4>The intraoperative electrocorticography records of 20 patients with temporal lobe epilepsy were analyzed in search of interictal synchronization clusters. Synchronization was analyzed, and the stability of highly synchronized areas was quantified. Surrogate data were constructed and used to statistically validate the results. Our results show the existence of highly localized and stable synchronization areas in both the lateral and the mesial areas of the temporal lobe ipsilateral to the clinical seizures. Synchronization areas seem to play a central role in the capacity of the epileptic network to generate clinical seizures. Resection of stable synchronization areas is associated with elimination of seizures; nonresection of synchronization clusters is associated with the persistence of seizures after surgery.<h4>Discussion</h4>We suggest that synchronization clusters and their stability play a central role in the epileptic network, favoring seizure onset and propagation. We further speculate that the stability distribution of these synchronization areas would differentiate normal from pathologic cases.
format	article
author	Agostina Palmigiano Jesús Pastor Rafael García de Sola Guillermo J Ortega
author_facet	Agostina Palmigiano Jesús Pastor Rafael García de Sola Guillermo J Ortega
author_sort	Agostina Palmigiano
title	Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
title_short	Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
title_full	Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
title_fullStr	Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
title_full_unstemmed	Stability of synchronization clusters and seizurability in temporal lobe epilepsy.
title_sort	stability of synchronization clusters and seizurability in temporal lobe epilepsy.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c701d6dc7de848ee9f67fc653f80ab56
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Stability of synchronization clusters and seizurability in temporal lobe epilepsy.

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