BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins

BCL9 is an activator of oncogenic Wnt/β-catenin. Here, the authors show a β-catenin independent function of BCL9 in a subtype of colorectal cancers, where it interacts with paraspeckle proteins to enhance the mRNA stability of calcium signalling and neural associated genes to promote communication w...

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Autores principales:	Meng Jiang, Yue Kang, Tomasz Sewastianik, Jiao Wang, Helen Tanton, Keith Alder, Peter Dennis, Yu Xin, Zhongqiu Wang, Ruiyang Liu, Mengyun Zhang, Ying Huang, Massimo Loda, Amitabh Srivastava, Runsheng Chen, Ming Liu, Ruben D. Carrasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c701f702b6ee44eb8abe1ba9329267b9
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spelling	oai:doaj.org-article:c701f702b6ee44eb8abe1ba9329267b92021-12-02T17:31:08ZBCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins10.1038/s41467-019-13842-72041-1723https://doaj.org/article/c701f702b6ee44eb8abe1ba9329267b92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13842-7https://doaj.org/toc/2041-1723BCL9 is an activator of oncogenic Wnt/β-catenin. Here, the authors show a β-catenin independent function of BCL9 in a subtype of colorectal cancers, where it interacts with paraspeckle proteins to enhance the mRNA stability of calcium signalling and neural associated genes to promote communication with tumour cells and its microenvironment.Meng JiangYue KangTomasz SewastianikJiao WangHelen TantonKeith AlderPeter DennisYu XinZhongqiu WangRuiyang LiuMengyun ZhangYing HuangMassimo LodaAmitabh SrivastavaRunsheng ChenMing LiuRuben D. CarrascoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Jiang Yue Kang Tomasz Sewastianik Jiao Wang Helen Tanton Keith Alder Peter Dennis Yu Xin Zhongqiu Wang Ruiyang Liu Mengyun Zhang Ying Huang Massimo Loda Amitabh Srivastava Runsheng Chen Ming Liu Ruben D. Carrasco BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
description	BCL9 is an activator of oncogenic Wnt/β-catenin. Here, the authors show a β-catenin independent function of BCL9 in a subtype of colorectal cancers, where it interacts with paraspeckle proteins to enhance the mRNA stability of calcium signalling and neural associated genes to promote communication with tumour cells and its microenvironment.
format	article
author	Meng Jiang Yue Kang Tomasz Sewastianik Jiao Wang Helen Tanton Keith Alder Peter Dennis Yu Xin Zhongqiu Wang Ruiyang Liu Mengyun Zhang Ying Huang Massimo Loda Amitabh Srivastava Runsheng Chen Ming Liu Ruben D. Carrasco
author_facet	Meng Jiang Yue Kang Tomasz Sewastianik Jiao Wang Helen Tanton Keith Alder Peter Dennis Yu Xin Zhongqiu Wang Ruiyang Liu Mengyun Zhang Ying Huang Massimo Loda Amitabh Srivastava Runsheng Chen Ming Liu Ruben D. Carrasco
author_sort	Meng Jiang
title	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
title_short	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
title_full	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
title_fullStr	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
title_full_unstemmed	BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
title_sort	bcl9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c701f702b6ee44eb8abe1ba9329267b9
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BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins

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