The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis
HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.
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Nature Portfolio
2021
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oai:doaj.org-article:c702d84ac1fb4ff4b8091efb501878532021-12-02T15:52:50ZThe HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis10.1038/s41467-021-21535-32041-1723https://doaj.org/article/c702d84ac1fb4ff4b8091efb501878532021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21535-3https://doaj.org/toc/2041-1723HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.Fang ZhengJianing ChenXiaoqian ZhangZifeng WangJiewen ChenXiaorong LinHongyan HuangWenkui FuJing LiangWei WuBo LiHerui YaoHai HuErwei SongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Fang Zheng Jianing Chen Xiaoqian Zhang Zifeng Wang Jiewen Chen Xiaorong Lin Hongyan Huang Wenkui Fu Jing Liang Wei Wu Bo Li Herui Yao Hai Hu Erwei Song The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| description |
HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role. |
| format |
article |
| author |
Fang Zheng Jianing Chen Xiaoqian Zhang Zifeng Wang Jiewen Chen Xiaorong Lin Hongyan Huang Wenkui Fu Jing Liang Wei Wu Bo Li Herui Yao Hai Hu Erwei Song |
| author_facet |
Fang Zheng Jianing Chen Xiaoqian Zhang Zifeng Wang Jiewen Chen Xiaorong Lin Hongyan Huang Wenkui Fu Jing Liang Wei Wu Bo Li Herui Yao Hai Hu Erwei Song |
| author_sort |
Fang Zheng |
| title |
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| title_short |
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| title_full |
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| title_fullStr |
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| title_full_unstemmed |
The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis |
| title_sort |
hif-1α antisense long non-coding rna drives a positive feedback loop of hif-1α mediated transactivation and glycolysis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c702d84ac1fb4ff4b8091efb50187853 |
| work_keys_str_mv |
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