The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis

HIF1alpha is reported to drive tumourigenesis through activating glycolysis. Here, the authors show that HIFAL, the HIF1alpha antisense long non-coding RNA, and HIF1alpha form a positive feed-forward loop which is essential for HIF1a-mediated metabolic reprogramming and oncogenic role.

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Autores principales: Fang Zheng, Jianing Chen, Xiaoqian Zhang, Zifeng Wang, Jiewen Chen, Xiaorong Lin, Hongyan Huang, Wenkui Fu, Jing Liang, Wei Wu, Bo Li, Herui Yao, Hai Hu, Erwei Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/c702d84ac1fb4ff4b8091efb50187853
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