High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication

DNA ligase 1 (LIG1) finalizes eukaryotic nuclear DNA synthesis by sealing Okazaki fragments using DNA end-joining reactions. Here the authors, by studying an engineered low-fidelity LIG1, reveal that LIG1 is a highly accurate DNA ligase in vivo.

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Autores principales:	Jessica S. Williams, Percy P. Tumbale, Mercedes E. Arana, Julian A. Rana, R. Scott Williams, Thomas A. Kunkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7070beaf4664cbf8e117033397ef7e8
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spelling	oai:doaj.org-article:c7070beaf4664cbf8e117033397ef7e82021-12-02T11:50:29ZHigh-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication10.1038/s41467-020-20800-12041-1723https://doaj.org/article/c7070beaf4664cbf8e117033397ef7e82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20800-1https://doaj.org/toc/2041-1723DNA ligase 1 (LIG1) finalizes eukaryotic nuclear DNA synthesis by sealing Okazaki fragments using DNA end-joining reactions. Here the authors, by studying an engineered low-fidelity LIG1, reveal that LIG1 is a highly accurate DNA ligase in vivo.Jessica S. WilliamsPercy P. TumbaleMercedes E. AranaJulian A. RanaR. Scott WilliamsThomas A. KunkelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica S. Williams Percy P. Tumbale Mercedes E. Arana Julian A. Rana R. Scott Williams Thomas A. Kunkel High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
description	DNA ligase 1 (LIG1) finalizes eukaryotic nuclear DNA synthesis by sealing Okazaki fragments using DNA end-joining reactions. Here the authors, by studying an engineered low-fidelity LIG1, reveal that LIG1 is a highly accurate DNA ligase in vivo.
format	article
author	Jessica S. Williams Percy P. Tumbale Mercedes E. Arana Julian A. Rana R. Scott Williams Thomas A. Kunkel
author_facet	Jessica S. Williams Percy P. Tumbale Mercedes E. Arana Julian A. Rana R. Scott Williams Thomas A. Kunkel
author_sort	Jessica S. Williams
title	High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
title_short	High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
title_full	High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
title_fullStr	High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
title_full_unstemmed	High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication
title_sort	high-fidelity dna ligation enforces accurate okazaki fragment maturation during dna replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7070beaf4664cbf8e117033397ef7e8
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High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication

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