A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Activation of the tumor suppressor p53 is a promising approach in cancer therapy. Here, the authors discover a series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3.
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Nature Portfolio
2018
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oai:doaj.org-article:c70bab1df6ec4076bb2c93aa455abeeb2021-12-02T14:39:27ZA DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage10.1038/s41467-018-03441-32041-1723https://doaj.org/article/c70bab1df6ec4076bb2c93aa455abeeb2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03441-3https://doaj.org/toc/2041-1723Activation of the tumor suppressor p53 is a promising approach in cancer therapy. Here, the authors discover a series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3.Marcus J. G. W. LaddsIngeborg M. M. van LeeuwenCatherine J. DrummondSu ChuAlan R. HealyGergana PopovaAndrés Pastor FernándezTanzina MollickSuhas DarekarSaikiran K. SedimbiMarta NekulovaMarijke C. C. SachwehJohanna CampbellMaureen HigginsChloe TuckMihaela PopaMireia Mayoral SafontPascal GelebartZinayida FandalyukAlastair M. ThompsonRichard SvenssonAnna-Lena GustavssonLars JohanssonKatarina FärnegårdhUlrika YngveAljona SalehMartin HaraldssonAgathe C. A. D’HollanderMarcela FrancoYan ZhaoMaria HåkanssonBjörn WalseKarin LarssonEmma M. PeatVicent PelechanoJohn LunecBorivoj VojtesekMar CarmenaWilliam C. EarnshawAnna R. McCarthyNicholas J. WestwoodMarie Arsenian-HenrikssonDavid P. LaneRavi BhatiaEmmet McCormackSonia LaínNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Marcus J. G. W. Ladds Ingeborg M. M. van Leeuwen Catherine J. Drummond Su Chu Alan R. Healy Gergana Popova Andrés Pastor Fernández Tanzina Mollick Suhas Darekar Saikiran K. Sedimbi Marta Nekulova Marijke C. C. Sachweh Johanna Campbell Maureen Higgins Chloe Tuck Mihaela Popa Mireia Mayoral Safont Pascal Gelebart Zinayida Fandalyuk Alastair M. Thompson Richard Svensson Anna-Lena Gustavsson Lars Johansson Katarina Färnegårdh Ulrika Yngve Aljona Saleh Martin Haraldsson Agathe C. A. D’Hollander Marcela Franco Yan Zhao Maria Håkansson Björn Walse Karin Larsson Emma M. Peat Vicent Pelechano John Lunec Borivoj Vojtesek Mar Carmena William C. Earnshaw Anna R. McCarthy Nicholas J. Westwood Marie Arsenian-Henriksson David P. Lane Ravi Bhatia Emmet McCormack Sonia Laín A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| description |
Activation of the tumor suppressor p53 is a promising approach in cancer therapy. Here, the authors discover a series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3. |
| format |
article |
| author |
Marcus J. G. W. Ladds Ingeborg M. M. van Leeuwen Catherine J. Drummond Su Chu Alan R. Healy Gergana Popova Andrés Pastor Fernández Tanzina Mollick Suhas Darekar Saikiran K. Sedimbi Marta Nekulova Marijke C. C. Sachweh Johanna Campbell Maureen Higgins Chloe Tuck Mihaela Popa Mireia Mayoral Safont Pascal Gelebart Zinayida Fandalyuk Alastair M. Thompson Richard Svensson Anna-Lena Gustavsson Lars Johansson Katarina Färnegårdh Ulrika Yngve Aljona Saleh Martin Haraldsson Agathe C. A. D’Hollander Marcela Franco Yan Zhao Maria Håkansson Björn Walse Karin Larsson Emma M. Peat Vicent Pelechano John Lunec Borivoj Vojtesek Mar Carmena William C. Earnshaw Anna R. McCarthy Nicholas J. Westwood Marie Arsenian-Henriksson David P. Lane Ravi Bhatia Emmet McCormack Sonia Laín |
| author_facet |
Marcus J. G. W. Ladds Ingeborg M. M. van Leeuwen Catherine J. Drummond Su Chu Alan R. Healy Gergana Popova Andrés Pastor Fernández Tanzina Mollick Suhas Darekar Saikiran K. Sedimbi Marta Nekulova Marijke C. C. Sachweh Johanna Campbell Maureen Higgins Chloe Tuck Mihaela Popa Mireia Mayoral Safont Pascal Gelebart Zinayida Fandalyuk Alastair M. Thompson Richard Svensson Anna-Lena Gustavsson Lars Johansson Katarina Färnegårdh Ulrika Yngve Aljona Saleh Martin Haraldsson Agathe C. A. D’Hollander Marcela Franco Yan Zhao Maria Håkansson Björn Walse Karin Larsson Emma M. Peat Vicent Pelechano John Lunec Borivoj Vojtesek Mar Carmena William C. Earnshaw Anna R. McCarthy Nicholas J. Westwood Marie Arsenian-Henriksson David P. Lane Ravi Bhatia Emmet McCormack Sonia Laín |
| author_sort |
Marcus J. G. W. Ladds |
| title |
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| title_short |
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| title_full |
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| title_fullStr |
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| title_full_unstemmed |
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| title_sort |
dhodh inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/c70bab1df6ec4076bb2c93aa455abeeb |
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