Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis
Immunoglobulin γ-1 heavy chain constant region (IGHG1) is a functional isoform of immunoglobulins and plays an important role in the cytolytic activity of immune effector cells. Dysregulated IGHG1 was implicated in the occurrence and development of various tumors. Protoporphyrin IX (PpIX) is an endo...
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| Main Authors: | , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
De Gruyter
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/c70cbe931e124d34880f49b5f651be22 |
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