Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants

Abstract Cholesteryl ester transfer protein (CETP) regulates high density lipoproteins (HDL)-cholesterol (C) and HDL-C is essential for fetal development. We hypothesized that women giving birth to large-for-gestational-age (LGA) and small-for-gestational age (SGA) infants differed in longitudinal c...

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Autores principales:	Marie Cecilie Paasche Roland, Kristin Godang, Pål Aukrust, Tore Henriksen, Tove Lekva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c70f76b362dd4263b50cfbd4bc7a47e3
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spelling	oai:doaj.org-article:c70f76b362dd4263b50cfbd4bc7a47e32021-12-02T17:05:46ZLow CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants10.1038/s41598-021-85777-32045-2322https://doaj.org/article/c70f76b362dd4263b50cfbd4bc7a47e32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85777-3https://doaj.org/toc/2045-2322Abstract Cholesteryl ester transfer protein (CETP) regulates high density lipoproteins (HDL)-cholesterol (C) and HDL-C is essential for fetal development. We hypothesized that women giving birth to large-for-gestational-age (LGA) and small-for-gestational age (SGA) infants differed in longitudinal changes in lipoproteins, CETP activity and HDL-C and that placentas from women with higher or lower circulating HDL-C displayed differential expression of mRNAs involved in cholesterol/nutrient transport, insulin signaling, inflammation/ extracellular matrix (ECM) remodeling. Circulating lipids and CETP activity was measured during pregnancy, NMR lipidomics in late pregnancy, and associations with LGA and SGA infants investigated. RNA sequencing was performed in 28 placentas according to higher and lower maternal HDL-C levels. Lipidomics revealed high triglycerides in large VLDL and lipids/cholesterol/cholesteryl esters in small HDL in women giving birth to SGA infants. Placentas from women with higher HDL-C had decreased levels of CETP expression which was associated with mRNAs involved in cholesterol/nutrient transport, insulin signaling and inflammation/ECM remodeling. Both placental and circulating CETP levels were associated with growth of the fetus. Low circulating CETP activity at 36–38 weeks was associated with giving birth to SGA infants. Our findings suggest a link between increased maternal HDL-C levels, low CETP levels both in circulation and placenta, and SGA infants.Marie Cecilie Paasche RolandKristin GodangPål AukrustTore HenriksenTove LekvaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Cecilie Paasche Roland Kristin Godang Pål Aukrust Tore Henriksen Tove Lekva Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
description	Abstract Cholesteryl ester transfer protein (CETP) regulates high density lipoproteins (HDL)-cholesterol (C) and HDL-C is essential for fetal development. We hypothesized that women giving birth to large-for-gestational-age (LGA) and small-for-gestational age (SGA) infants differed in longitudinal changes in lipoproteins, CETP activity and HDL-C and that placentas from women with higher or lower circulating HDL-C displayed differential expression of mRNAs involved in cholesterol/nutrient transport, insulin signaling, inflammation/ extracellular matrix (ECM) remodeling. Circulating lipids and CETP activity was measured during pregnancy, NMR lipidomics in late pregnancy, and associations with LGA and SGA infants investigated. RNA sequencing was performed in 28 placentas according to higher and lower maternal HDL-C levels. Lipidomics revealed high triglycerides in large VLDL and lipids/cholesterol/cholesteryl esters in small HDL in women giving birth to SGA infants. Placentas from women with higher HDL-C had decreased levels of CETP expression which was associated with mRNAs involved in cholesterol/nutrient transport, insulin signaling and inflammation/ECM remodeling. Both placental and circulating CETP levels were associated with growth of the fetus. Low circulating CETP activity at 36–38 weeks was associated with giving birth to SGA infants. Our findings suggest a link between increased maternal HDL-C levels, low CETP levels both in circulation and placenta, and SGA infants.
format	article
author	Marie Cecilie Paasche Roland Kristin Godang Pål Aukrust Tore Henriksen Tove Lekva
author_facet	Marie Cecilie Paasche Roland Kristin Godang Pål Aukrust Tore Henriksen Tove Lekva
author_sort	Marie Cecilie Paasche Roland
title	Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
title_short	Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
title_full	Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
title_fullStr	Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
title_full_unstemmed	Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants
title_sort	low cetp activity and unique composition of large vldl and small hdl in women giving birth to small-for-gestational age infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c70f76b362dd4263b50cfbd4bc7a47e3
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Low CETP activity and unique composition of large VLDL and small HDL in women giving birth to small-for-gestational age infants

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