Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers

Abstract Footpad dermatitis (FPD) is used in the poultry industry as an animal welfare criterion to determine stocking density. Trace minerals (TM) play a role in skin integrity and wound healing. This study evaluated the impact of TM on FPD and consisted of 3 treatments supplemented with 0 (NTM), l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juxing Chen, Guillermo Tellez, Jeffery Escobar, Mercedes Vazquez-Anon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c712f31acf904873ba83db9faa4e81f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c712f31acf904873ba83db9faa4e81f7
record_format	dspace
spelling	oai:doaj.org-article:c712f31acf904873ba83db9faa4e81f72021-12-02T16:06:08ZImpact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers10.1038/s41598-017-02026-22045-2322https://doaj.org/article/c712f31acf904873ba83db9faa4e81f72017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02026-2https://doaj.org/toc/2045-2322Abstract Footpad dermatitis (FPD) is used in the poultry industry as an animal welfare criterion to determine stocking density. Trace minerals (TM) play a role in skin integrity and wound healing. This study evaluated the impact of TM on FPD and consisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same basal diet. On d21, 71% birds in all treatments developed mild FPD and pens were top-dressed with dry litter to promote FPD healing. Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesion scores during d21–42, HTM reduced the AUC of FPD lesion scores during d7–21 and d21–42. LTM improved growth performance on d14, HTM improved growth performance on d14 and d28. LTM and/or HTM increased gene expression of VEGF, TIMP3, TIMP4, MMP13, ITGA2, ITGA3 and CD40, which promoted collagen synthesis, deposition and organization; cell migration, matrix remodeling, and angiogenesis. LTM and/or HTM increased inflammation by upregulating TNFα and IL-1β during the early wound healing phase and reduced inflammation by downregulating IL-1β during the late wound healing phase. Our findings showed that TM not only improved growth performance but also reduced FPD development by promoting FPD wound healing.Juxing ChenGuillermo TellezJeffery EscobarMercedes Vazquez-AnonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juxing Chen Guillermo Tellez Jeffery Escobar Mercedes Vazquez-Anon Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
description	Abstract Footpad dermatitis (FPD) is used in the poultry industry as an animal welfare criterion to determine stocking density. Trace minerals (TM) play a role in skin integrity and wound healing. This study evaluated the impact of TM on FPD and consisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same basal diet. On d21, 71% birds in all treatments developed mild FPD and pens were top-dressed with dry litter to promote FPD healing. Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesion scores during d21–42, HTM reduced the AUC of FPD lesion scores during d7–21 and d21–42. LTM improved growth performance on d14, HTM improved growth performance on d14 and d28. LTM and/or HTM increased gene expression of VEGF, TIMP3, TIMP4, MMP13, ITGA2, ITGA3 and CD40, which promoted collagen synthesis, deposition and organization; cell migration, matrix remodeling, and angiogenesis. LTM and/or HTM increased inflammation by upregulating TNFα and IL-1β during the early wound healing phase and reduced inflammation by downregulating IL-1β during the late wound healing phase. Our findings showed that TM not only improved growth performance but also reduced FPD development by promoting FPD wound healing.
format	article
author	Juxing Chen Guillermo Tellez Jeffery Escobar Mercedes Vazquez-Anon
author_facet	Juxing Chen Guillermo Tellez Jeffery Escobar Mercedes Vazquez-Anon
author_sort	Juxing Chen
title	Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
title_short	Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
title_full	Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
title_fullStr	Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
title_full_unstemmed	Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers
title_sort	impact of trace minerals on wound healing of footpad dermatitis in broilers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c712f31acf904873ba83db9faa4e81f7
work_keys_str_mv	AT juxingchen impactoftracemineralsonwoundhealingoffootpaddermatitisinbroilers AT guillermotellez impactoftracemineralsonwoundhealingoffootpaddermatitisinbroilers AT jefferyescobar impactoftracemineralsonwoundhealingoffootpaddermatitisinbroilers AT mercedesvazquezanon impactoftracemineralsonwoundhealingoffootpaddermatitisinbroilers
_version_	1718385113853591552

Impact of Trace Minerals on Wound Healing of Footpad Dermatitis in Broilers

Ejemplares similares