Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion

Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown. Here, the authors show that interaction of Sec3 with Sso2 on the plasma membrane promotes formation of an Sso2–Sec9 comp...

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Autores principales:	Peng Yue, Yubo Zhang, Kunrong Mei, Shaoxiao Wang, Johannes Lesigang, Yueyao Zhu, Gang Dong, Wei Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c713cdd2ea5a4982ac422879d68dd22a
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spelling	oai:doaj.org-article:c713cdd2ea5a4982ac422879d68dd22a2021-12-02T14:40:56ZSec3 promotes the initial binary t-SNARE complex assembly and membrane fusion10.1038/ncomms142362041-1723https://doaj.org/article/c713cdd2ea5a4982ac422879d68dd22a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14236https://doaj.org/toc/2041-1723Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown. Here, the authors show that interaction of Sec3 with Sso2 on the plasma membrane promotes formation of an Sso2–Sec9 complex, an early step in SNARE assembly, likely by inhibiting Sso2 auto-inhibition.Peng YueYubo ZhangKunrong MeiShaoxiao WangJohannes LesigangYueyao ZhuGang DongWei GuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Yue Yubo Zhang Kunrong Mei Shaoxiao Wang Johannes Lesigang Yueyao Zhu Gang Dong Wei Guo Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
description	Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown. Here, the authors show that interaction of Sec3 with Sso2 on the plasma membrane promotes formation of an Sso2–Sec9 complex, an early step in SNARE assembly, likely by inhibiting Sso2 auto-inhibition.
format	article
author	Peng Yue Yubo Zhang Kunrong Mei Shaoxiao Wang Johannes Lesigang Yueyao Zhu Gang Dong Wei Guo
author_facet	Peng Yue Yubo Zhang Kunrong Mei Shaoxiao Wang Johannes Lesigang Yueyao Zhu Gang Dong Wei Guo
author_sort	Peng Yue
title	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
title_short	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
title_full	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
title_fullStr	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
title_full_unstemmed	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion
title_sort	sec3 promotes the initial binary t-snare complex assembly and membrane fusion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c713cdd2ea5a4982ac422879d68dd22a
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Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion

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