Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell f...

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Autores principales:	Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, Herbert Virgin, Fiona M. Menzies, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c71934f520734080a9c2a869599163df
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spelling	oai:doaj.org-article:c71934f520734080a9c2a869599163df2021-12-02T15:34:59ZAutophagy regulates Notch degradation and modulates stem cell development and neurogenesis10.1038/ncomms105332041-1723https://doaj.org/article/c71934f520734080a9c2a869599163df2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10533https://doaj.org/toc/2041-1723The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate.Xiaoting WuAngeleen FlemingThomas RickettsMariana PavelHerbert VirginFiona M. MenziesDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
description	The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al.identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate.
format	article
author	Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein
author_facet	Xiaoting Wu Angeleen Fleming Thomas Ricketts Mariana Pavel Herbert Virgin Fiona M. Menzies David C. Rubinsztein
author_sort	Xiaoting Wu
title	Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
title_short	Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
title_full	Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
title_fullStr	Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
title_full_unstemmed	Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis
title_sort	autophagy regulates notch degradation and modulates stem cell development and neurogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c71934f520734080a9c2a869599163df
work_keys_str_mv	AT xiaotingwu autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT angeleenfleming autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT thomasricketts autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT marianapavel autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT herbertvirgin autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT fionammenzies autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis AT davidcrubinsztein autophagyregulatesnotchdegradationandmodulatesstemcelldevelopmentandneurogenesis
_version_	1718386681497780224

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

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