Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications

Kelly C Pearson1, April W Armstrong21Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 2Department of Dermatology, University of California, Davis, Sacramento, CA, USAAbstract: Psoriasis is a systemic inflammatory disorder, which has been reported to be...

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Autores principales:	Pearson KC, Armstrong AW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/c71c8073ca0a4f2aa22b333b44897274
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spelling	oai:doaj.org-article:c71c8073ca0a4f2aa22b333b448972742021-12-02T02:04:38ZPsoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications2230-326Xhttps://doaj.org/article/c71c8073ca0a4f2aa22b333b448972742012-01-01T00:00:00Zhttp://www.dovepress.com/psoriasis-and-cardiovascular-disease-epidemiology-mechanisms-and-clini-a9055https://doaj.org/toc/2230-326XKelly C Pearson1, April W Armstrong21Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 2Department of Dermatology, University of California, Davis, Sacramento, CA, USAAbstract: Psoriasis is a systemic inflammatory disorder, which has been reported to be associated with adverse cardiovascular (CV) risks. CV comorbidities, such as diabetes, dyslipidemia, hypertension, and obesity appear to be increased in psoriasis patients compared with the general population. Psoriasis may contribute independently to adverse cardiac outcomes after accounting for traditional CV risk factors. In this article, it was aimed to summarize large population studies that examine the relationship between psoriasis and CV risk factors and major adverse cardiac outcomes, and highlight proposed mechanisms for the observed epidemiologic link. Specifically, large population-based studies with over 1000 total subjects from 1975 to September 2008 in the English literature are highlighted. The relevant search terms in the Ovid Medline database were applied. The majority of the studies presented evidence for an increased incidence of CV risk factors and an increased risk for major adverse cardiac outcomes in patients with severe psoriasis. The increased risk in severe psoriasis necessitates regular screening for other comorbidities. Current guidelines for screening CV risk factors among psoriasis patients are discussed. Also reviewed is the scarce literature in therapeutic strategies to reduce CV risk factors and major adverse cardiac outcomes in psoriasis patients. Specifically, an emerging area of research on the effects of biologic agents on CV risk factors and CV adverse outcomes in psoriasis is discussed.Keywords: cardiovascular disease, cardiovascular risk factors, psoriasis, diabetes mellitus, myocardial infarction, major adverse cardiovascular events, MACE, hypertensionPearson KCArmstrong AWDove Medical PressarticleDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2012, Iss default, Pp 1-11 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Pearson KC Armstrong AW Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
description	Kelly C Pearson1, April W Armstrong21Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 2Department of Dermatology, University of California, Davis, Sacramento, CA, USAAbstract: Psoriasis is a systemic inflammatory disorder, which has been reported to be associated with adverse cardiovascular (CV) risks. CV comorbidities, such as diabetes, dyslipidemia, hypertension, and obesity appear to be increased in psoriasis patients compared with the general population. Psoriasis may contribute independently to adverse cardiac outcomes after accounting for traditional CV risk factors. In this article, it was aimed to summarize large population studies that examine the relationship between psoriasis and CV risk factors and major adverse cardiac outcomes, and highlight proposed mechanisms for the observed epidemiologic link. Specifically, large population-based studies with over 1000 total subjects from 1975 to September 2008 in the English literature are highlighted. The relevant search terms in the Ovid Medline database were applied. The majority of the studies presented evidence for an increased incidence of CV risk factors and an increased risk for major adverse cardiac outcomes in patients with severe psoriasis. The increased risk in severe psoriasis necessitates regular screening for other comorbidities. Current guidelines for screening CV risk factors among psoriasis patients are discussed. Also reviewed is the scarce literature in therapeutic strategies to reduce CV risk factors and major adverse cardiac outcomes in psoriasis patients. Specifically, an emerging area of research on the effects of biologic agents on CV risk factors and CV adverse outcomes in psoriasis is discussed.Keywords: cardiovascular disease, cardiovascular risk factors, psoriasis, diabetes mellitus, myocardial infarction, major adverse cardiovascular events, MACE, hypertension
format	article
author	Pearson KC Armstrong AW
author_facet	Pearson KC Armstrong AW
author_sort	Pearson KC
title	Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
title_short	Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
title_full	Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
title_fullStr	Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
title_full_unstemmed	Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
title_sort	psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c71c8073ca0a4f2aa22b333b44897274
work_keys_str_mv	AT pearsonkc psoriasisandcardiovasculardiseaseepidemiologymechanismsandclinicalimplications AT armstrongaw psoriasisandcardiovasculardiseaseepidemiologymechanismsandclinicalimplications
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Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications

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