Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration

Abstract The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, − 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marta Kozłowska, Jakub Kortas, Małgorzata Żychowska, Jędrzej Antosiewicz, Klaudia Żuczek, Silvia Perego, Giovanni Lombardi, Ewa Ziemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c71eae30a46a4105bc41609b22b551fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c71eae30a46a4105bc41609b22b551fe
record_format	dspace
spelling	oai:doaj.org-article:c71eae30a46a4105bc41609b22b551fe2021-12-02T14:25:21ZBeneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration10.1038/s41598-021-86430-92045-2322https://doaj.org/article/c71eae30a46a4105bc41609b22b551fe2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86430-9https://doaj.org/toc/2045-2322Abstract The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, − 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Baseline myostatin correlated significantly with visceral fat area, glucose, insulin, HOMA-IR and irisin (all p < 0.05). The single session of WBC induced temporary changes in AA profile, whereas chronic exposure lowered valine and asparagine concentrations (p < 0.01 and p = 0.01, respectively) compared to the baseline. The chronic WBC reduced fasting glucose (p = 0.04), FGF21 (− 35.8%, p = 0.06) and myostatin (-18.2%, p = 0.06). Still, the effects were age-dependent. The decrease of myostatin was more pronounced in middle-aged participants (p < 0.01). Concentrations of irisin and adiponectin increased in response to chronic WBC, while BDNF level remained unchanged. By improving the adipo-myokine profile, chronic WBC may reduce effectively the risk of the metabolic syndrome associated with hyperinsulinemia, increased levels of valine and asparagine, and muscle atrophy.Marta KozłowskaJakub KortasMałgorzata ŻychowskaJędrzej AntosiewiczKlaudia ŻuczekSilvia PeregoGiovanni LombardiEwa ZiemannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Kozłowska Jakub Kortas Małgorzata Żychowska Jędrzej Antosiewicz Klaudia Żuczek Silvia Perego Giovanni Lombardi Ewa Ziemann Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
description	Abstract The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, − 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Baseline myostatin correlated significantly with visceral fat area, glucose, insulin, HOMA-IR and irisin (all p < 0.05). The single session of WBC induced temporary changes in AA profile, whereas chronic exposure lowered valine and asparagine concentrations (p < 0.01 and p = 0.01, respectively) compared to the baseline. The chronic WBC reduced fasting glucose (p = 0.04), FGF21 (− 35.8%, p = 0.06) and myostatin (-18.2%, p = 0.06). Still, the effects were age-dependent. The decrease of myostatin was more pronounced in middle-aged participants (p < 0.01). Concentrations of irisin and adiponectin increased in response to chronic WBC, while BDNF level remained unchanged. By improving the adipo-myokine profile, chronic WBC may reduce effectively the risk of the metabolic syndrome associated with hyperinsulinemia, increased levels of valine and asparagine, and muscle atrophy.
format	article
author	Marta Kozłowska Jakub Kortas Małgorzata Żychowska Jędrzej Antosiewicz Klaudia Żuczek Silvia Perego Giovanni Lombardi Ewa Ziemann
author_facet	Marta Kozłowska Jakub Kortas Małgorzata Żychowska Jędrzej Antosiewicz Klaudia Żuczek Silvia Perego Giovanni Lombardi Ewa Ziemann
author_sort	Marta Kozłowska
title	Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
title_short	Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
title_full	Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
title_fullStr	Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
title_full_unstemmed	Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
title_sort	beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c71eae30a46a4105bc41609b22b551fe
work_keys_str_mv	AT martakozłowska beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT jakubkortas beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT małgorzatazychowska beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT jedrzejantosiewicz beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT klaudiazuczek beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT silviaperego beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT giovannilombardi beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration AT ewaziemann beneficialeffectsofwholebodycryotherapyonglucosehomeostasisandaminoacidprofileareassociatedwithareducedmyostatinserumconcentration
_version_	1718391394910863360

Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration

Ejemplares similares