The structure-function relationship of disulfide bonds in etanercept

The structure-function relationship of disulfide bonds in etanercept

Abstract Etanercept is a TNFα receptor Fc fusion protein used for the treatment of rheumatic disease and psoriasis. Physicochemical and functional investigation of process fractions during development of the etanercept biosimilar GP2015 (Erelzi®) revealed a correlation between reduced potency and in...

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Bibliographic Details
Main Authors: William C. Lamanna, Robert Ernst Mayer, Alfred Rupprechter, Michael Fuchs, Fabian Higel, Cornelius Fritsch, Cornelia Vogelsang, Andreas Seidl, Hansjoerg Toll, Martin Schiestl, Johann Holzmann
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/c7209dcd6ffd42fea8b0b256f819198c
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https://doaj.org/article/c7209dcd6ffd42fea8b0b256f819198c

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