The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.

Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relati...

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Autores principales: Manel Puig-Domingo, Raúl M Luque, Jordi L Reverter, Laura M López-Sánchez, Manuel D Gahete, Michael D Culler, Gonzalo Díaz-Soto, Francisco Lomeña, Mattia Squarcia, José Luis Mate, Mireia Mora, Laureano Fernández-Cruz, Oscar Vidal, Antonio Alastrué, Jose Balibrea, Irene Halperin, Dídac Mauricio, Justo P Castaño
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spelling oai:doaj.org-article:c720d5555a354221b8e584d4004b00a52021-11-18T08:37:01ZThe truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.1932-620310.1371/journal.pone.0085527https://doaj.org/article/c720d5555a354221b8e584d4004b00a52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465589/?tool=EBIhttps://doaj.org/toc/1932-6203Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relationship with the efficacy of somatostatin analog treatment. Thirty-nine cases of thyroid carcinoma were evaluated (20 PDTC and 19 WDTC). Depreotide scintigraphy and mRNA levels of sst-subtypes, including the truncated variant sst5TMD4, were carried out. Depreotide scans were positive in the recurrent tumor in the neck in 6 of 11 (54%) PDTC, and in those with lung metastases in 5/11 cases (45.4%); sst5TMD4 was present in 18/20 (90%) of PDTC, being the most densely expressed sst-subtype, with a 20-fold increase in relation to sst2. In WDTC, sst2 was the most represented, while sst5TMD4 was not found; sst2 was significantly increased in PDTC in comparison to WDTC. Five depreotide positive PDTC received octreotide for 3-6 months in a pilot study with no changes in the size of the lesions in 3 of them, and a significant increase in the pulmonary and cervical lesions in the other 2. All PDTC patients treated with octreotide showed high expression of sst5TMD4. ROC curve analysis demonstrated that only sst5TMD4 discriminates between PDTC and WDTC. We conclude that sst5TMD4 is overexpressed in PDTC and may be involved in the lack of response to somatostatin analogue treatment.Manel Puig-DomingoRaúl M LuqueJordi L ReverterLaura M López-SánchezManuel D GaheteMichael D CullerGonzalo Díaz-SotoFrancisco LomeñaMattia SquarciaJosé Luis MateMireia MoraLaureano Fernández-CruzOscar VidalAntonio AlastruéJose BalibreaIrene HalperinDídac MauricioJusto P CastañoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85527 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Manel Puig-Domingo
Raúl M Luque
Jordi L Reverter
Laura M López-Sánchez
Manuel D Gahete
Michael D Culler
Gonzalo Díaz-Soto
Francisco Lomeña
Mattia Squarcia
José Luis Mate
Mireia Mora
Laureano Fernández-Cruz
Oscar Vidal
Antonio Alastrué
Jose Balibrea
Irene Halperin
Dídac Mauricio
Justo P Castaño
The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
description Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relationship with the efficacy of somatostatin analog treatment. Thirty-nine cases of thyroid carcinoma were evaluated (20 PDTC and 19 WDTC). Depreotide scintigraphy and mRNA levels of sst-subtypes, including the truncated variant sst5TMD4, were carried out. Depreotide scans were positive in the recurrent tumor in the neck in 6 of 11 (54%) PDTC, and in those with lung metastases in 5/11 cases (45.4%); sst5TMD4 was present in 18/20 (90%) of PDTC, being the most densely expressed sst-subtype, with a 20-fold increase in relation to sst2. In WDTC, sst2 was the most represented, while sst5TMD4 was not found; sst2 was significantly increased in PDTC in comparison to WDTC. Five depreotide positive PDTC received octreotide for 3-6 months in a pilot study with no changes in the size of the lesions in 3 of them, and a significant increase in the pulmonary and cervical lesions in the other 2. All PDTC patients treated with octreotide showed high expression of sst5TMD4. ROC curve analysis demonstrated that only sst5TMD4 discriminates between PDTC and WDTC. We conclude that sst5TMD4 is overexpressed in PDTC and may be involved in the lack of response to somatostatin analogue treatment.
format article
author Manel Puig-Domingo
Raúl M Luque
Jordi L Reverter
Laura M López-Sánchez
Manuel D Gahete
Michael D Culler
Gonzalo Díaz-Soto
Francisco Lomeña
Mattia Squarcia
José Luis Mate
Mireia Mora
Laureano Fernández-Cruz
Oscar Vidal
Antonio Alastrué
Jose Balibrea
Irene Halperin
Dídac Mauricio
Justo P Castaño
author_facet Manel Puig-Domingo
Raúl M Luque
Jordi L Reverter
Laura M López-Sánchez
Manuel D Gahete
Michael D Culler
Gonzalo Díaz-Soto
Francisco Lomeña
Mattia Squarcia
José Luis Mate
Mireia Mora
Laureano Fernández-Cruz
Oscar Vidal
Antonio Alastrué
Jose Balibrea
Irene Halperin
Dídac Mauricio
Justo P Castaño
author_sort Manel Puig-Domingo
title The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
title_short The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
title_full The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
title_fullStr The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
title_full_unstemmed The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.
title_sort truncated isoform of somatostatin receptor5 (sst5tmd4) is associated with poorly differentiated thyroid cancer.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/c720d5555a354221b8e584d4004b00a5
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