Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution

Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution

Abstract Astatine-211 (211At)-labeled phenylalanine is expected to be a promising agent for targeted alpha-particle therapy for the treatment of patients with glioma. The existing reactions to prepare the labeled compound usually require organic solvents and metals that are toxic and hazardous to th...

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Main Authors: Yoshifumi Shirakami, Tadashi Watabe, Honoka Obata, Kazuko Kaneda, Kazuhiro Ooe, Yuwei Liu, Takahiro Teramoto, Atsushi Toyoshima, Atsushi Shinohara, Eku Shimosegawa, Jun Hatazawa, Koichi Fukase
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/c725b93b6496492c9ff9377e5a3890d6
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https://doaj.org/article/c725b93b6496492c9ff9377e5a3890d6

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