Quantifying compressive forces between living cell layers and within tissues using elastic round microgels

Increasing importance is placed upon the effect of mechanical forces on cell regulation, fate and disease states. Here, the authors describe a deformable fluorescent nanoparticle labeled elastic microsphere which can be used to calculate strain and traction forces in vitro and in vivo.

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Auteurs principaux: Erfan Mohagheghian, Junyu Luo, Junjian Chen, Gaurav Chaudhary, Junwei Chen, Jian Sun, Randy H. Ewoldt, Ning Wang
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/c72b3aa206494ddc9840377829e15d7e
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Résumé:Increasing importance is placed upon the effect of mechanical forces on cell regulation, fate and disease states. Here, the authors describe a deformable fluorescent nanoparticle labeled elastic microsphere which can be used to calculate strain and traction forces in vitro and in vivo.