Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation

Akihiro Tojo, Saaya Hatakeyama, Satoshi Kinugasa, Masaomi Nangaku Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan Abstract: The kidney plays an important role in gluconeogenesis during starvation. To clarify the anti-diabetic action of angiotensin receptor blockers,...

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Autores principales:	Tojo A, Hatakeyama S, Kinugasa S, Nangaku M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c72ce5ea3a484f21b971acbada8e9afe
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spelling	oai:doaj.org-article:c72ce5ea3a484f21b971acbada8e9afe2021-12-02T02:30:40ZAngiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation1178-7007https://doaj.org/article/c72ce5ea3a484f21b971acbada8e9afe2015-02-01T00:00:00Zhttp://www.dovepress.com/angiotensin-receptor-blocker-telmisartan-suppresses-renal-gluconeogene-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Akihiro Tojo, Saaya Hatakeyama, Satoshi Kinugasa, Masaomi Nangaku Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan Abstract: The kidney plays an important role in gluconeogenesis during starvation. To clarify the anti-diabetic action of angiotensin receptor blockers, we examined the effects of telmisartan on the sodium-glucose co-transporters (SGLT) and the pathways of renal gluconeogenesis in streptozotocin-induced diabetes mellitus (DM) rats. At 4 weeks, the DM rats treated with/without telmisartan for 2 weeks and normal control rats were used for the study after a 24-hour fast. SGLT2 expressed on the brush border membrane of the proximal convoluted tubules increased in the DM rats, but decreased in the rats treated with telmisartan. The expression of restriction enzymes of gluconeogenesis, glucose-6-phosphatase, and phosphoenolpyruvate carboxykinase increased in the proximal tubules in the DM rats, whereas these enzymes decreased in the kidneys of the rats treated with telmisartan. The elevated cytoplasmic glucose-6-phosphate and glucose levels in the kidney of DM rats significantly decreased in those treated with telmisartan, whereas those levels in the liver did not show significant change. Meanwhile, the high plasma glucose levels in the DM rats during the intravenous insulin tolerance tests were ameliorated by telmisartan. The increased fasting plasma glucose levels after 24 hours of starvation in the DM rats thus returned to the control levels by telmisartan treatment. In conclusion, the increased renal SGLT2 expression, elevated renal gluconeogenesis enzymes and extent of insulin-resistance in the DM rats were ameliorated by telmisartan therapy, thus resulting in decreased plasma glucose levels after 24 hours of fasting. Keywords: SGLT2, renal gluconeogenesis, diabetes, angiotensin IITojo AHatakeyama SKinugasa SNangaku MDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2015, Iss default, Pp 103-113 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Tojo A Hatakeyama S Kinugasa S Nangaku M Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
description	Akihiro Tojo, Saaya Hatakeyama, Satoshi Kinugasa, Masaomi Nangaku Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan Abstract: The kidney plays an important role in gluconeogenesis during starvation. To clarify the anti-diabetic action of angiotensin receptor blockers, we examined the effects of telmisartan on the sodium-glucose co-transporters (SGLT) and the pathways of renal gluconeogenesis in streptozotocin-induced diabetes mellitus (DM) rats. At 4 weeks, the DM rats treated with/without telmisartan for 2 weeks and normal control rats were used for the study after a 24-hour fast. SGLT2 expressed on the brush border membrane of the proximal convoluted tubules increased in the DM rats, but decreased in the rats treated with telmisartan. The expression of restriction enzymes of gluconeogenesis, glucose-6-phosphatase, and phosphoenolpyruvate carboxykinase increased in the proximal tubules in the DM rats, whereas these enzymes decreased in the kidneys of the rats treated with telmisartan. The elevated cytoplasmic glucose-6-phosphate and glucose levels in the kidney of DM rats significantly decreased in those treated with telmisartan, whereas those levels in the liver did not show significant change. Meanwhile, the high plasma glucose levels in the DM rats during the intravenous insulin tolerance tests were ameliorated by telmisartan. The increased fasting plasma glucose levels after 24 hours of starvation in the DM rats thus returned to the control levels by telmisartan treatment. In conclusion, the increased renal SGLT2 expression, elevated renal gluconeogenesis enzymes and extent of insulin-resistance in the DM rats were ameliorated by telmisartan therapy, thus resulting in decreased plasma glucose levels after 24 hours of fasting. Keywords: SGLT2, renal gluconeogenesis, diabetes, angiotensin II
format	article
author	Tojo A Hatakeyama S Kinugasa S Nangaku M
author_facet	Tojo A Hatakeyama S Kinugasa S Nangaku M
author_sort	Tojo A
title	Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
title_short	Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
title_full	Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
title_fullStr	Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
title_full_unstemmed	Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
title_sort	angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c72ce5ea3a484f21b971acbada8e9afe
work_keys_str_mv	AT tojoa angiotensinreceptorblockertelmisartansuppressesrenalgluconeogenesisduringstarvation AT hatakeyamas angiotensinreceptorblockertelmisartansuppressesrenalgluconeogenesisduringstarvation AT kinugasas angiotensinreceptorblockertelmisartansuppressesrenalgluconeogenesisduringstarvation AT nangakum angiotensinreceptorblockertelmisartansuppressesrenalgluconeogenesisduringstarvation
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Angiotensin receptor blocker telmisartan suppresses renal gluconeogenesis during starvation

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