Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

Traditionally, the leafy part of Andrographis paniculata (AP) and Moringa oleifera (MO) have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and com...

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Autores principales:	Johnson Ajeh Isaac, Kokonne Elizabeth Ekere, Ekeh Ezekiel, Isa Hayatu Galadima, Rashida Abdulahi, Ayuba Samali
Formato:	article
Lenguaje:	EN ID
Publicado:	Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya 2021
Materias:	Andrographis paniculata Moringa oleifera Hypertension Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/c72dd590855b4297aec581799665a5d6
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spelling	oai:doaj.org-article:c72dd590855b4297aec581799665a5d62021-12-01T04:44:09ZCompressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves10.33084/bjop.v4i4.25442621-4814https://doaj.org/article/c72dd590855b4297aec581799665a5d62021-11-01T00:00:00Zhttp://journal.umpalangkaraya.ac.id/index.php/bjop/article/view/2544https://doaj.org/toc/2621-4814Traditionally, the leafy part of Andrographis paniculata (AP) and Moringa oleifera (MO) have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of AP and MO were produced by compressing powders and granules at various compression pressure. Results show that MO met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression. Johnson Ajeh IsaacKokonne Elizabeth EkereEkeh EzekielIsa Hayatu GaladimaRashida AbdulahiAyuba SamaliInstitute for Researches and Community Services Universitas Muhammadiyah Palangkaraya articleAndrographis paniculataMoringa oleiferaHypertensionPharmacy and materia medicaRS1-441ENIDBorneo Journal of Pharmacy, Vol 4, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	Andrographis paniculata Moringa oleifera Hypertension Pharmacy and materia medica RS1-441
spellingShingle	Andrographis paniculata Moringa oleifera Hypertension Pharmacy and materia medica RS1-441 Johnson Ajeh Isaac Kokonne Elizabeth Ekere Ekeh Ezekiel Isa Hayatu Galadima Rashida Abdulahi Ayuba Samali Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
description	Traditionally, the leafy part of Andrographis paniculata (AP) and Moringa oleifera (MO) have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of AP and MO were produced by compressing powders and granules at various compression pressure. Results show that MO met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression.
format	article
author	Johnson Ajeh Isaac Kokonne Elizabeth Ekere Ekeh Ezekiel Isa Hayatu Galadima Rashida Abdulahi Ayuba Samali
author_facet	Johnson Ajeh Isaac Kokonne Elizabeth Ekere Ekeh Ezekiel Isa Hayatu Galadima Rashida Abdulahi Ayuba Samali
author_sort	Johnson Ajeh Isaac
title	Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
title_short	Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
title_full	Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
title_fullStr	Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
title_full_unstemmed	Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
title_sort	compressional physics of binary mixture of dried andrographis paniculata and moringa oleifera leaves
publisher	Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
publishDate	2021
url	https://doaj.org/article/c72dd590855b4297aec581799665a5d6
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Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

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