A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.
CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susce...
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2012
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oai:doaj.org-article:c72fbfdb2a4141708d5861e28637b7992021-11-18T08:14:15ZA soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.1932-620310.1371/journal.pone.0044654https://doaj.org/article/c72fbfdb2a4141708d5861e28637b7992012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049754/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence at significantly elevated levels of a circulating soluble form of CTLA-4 in 70% of B-ALL pediatric patients with active disease, the positive correlation between the percentage of leukemic B lymphocytes and the amount of serum sCTLA-4, and the expression of sCTLA-4 transcript by B cells in patients. Finally, a correlation between CD1d expression (a negative prognostic marker) and the sCTLA-4 in B-ALL patients was observed. This suggests a possible role of this soluble molecule as a marker of progression or severity of the neoplastic disease.Rita SimoneClaudya TencaFranco FaisMatteo LucianiGiulio De RossiGiampaola PesceMarcello BagnascoDaniele SaverinoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e44654 (2012) |
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Medicine R Science Q Rita Simone Claudya Tenca Franco Fais Matteo Luciani Giulio De Rossi Giampaola Pesce Marcello Bagnasco Daniele Saverino A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| description |
CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence at significantly elevated levels of a circulating soluble form of CTLA-4 in 70% of B-ALL pediatric patients with active disease, the positive correlation between the percentage of leukemic B lymphocytes and the amount of serum sCTLA-4, and the expression of sCTLA-4 transcript by B cells in patients. Finally, a correlation between CD1d expression (a negative prognostic marker) and the sCTLA-4 in B-ALL patients was observed. This suggests a possible role of this soluble molecule as a marker of progression or severity of the neoplastic disease. |
| format |
article |
| author |
Rita Simone Claudya Tenca Franco Fais Matteo Luciani Giulio De Rossi Giampaola Pesce Marcello Bagnasco Daniele Saverino |
| author_facet |
Rita Simone Claudya Tenca Franco Fais Matteo Luciani Giulio De Rossi Giampaola Pesce Marcello Bagnasco Daniele Saverino |
| author_sort |
Rita Simone |
| title |
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| title_short |
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| title_full |
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| title_fullStr |
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| title_full_unstemmed |
A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression. |
| title_sort |
soluble form of ctla-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with cd1d+ expression. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/c72fbfdb2a4141708d5861e28637b799 |
| work_keys_str_mv |
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