A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.

CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susce...

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Autores principales: Rita Simone, Claudya Tenca, Franco Fais, Matteo Luciani, Giulio De Rossi, Giampaola Pesce, Marcello Bagnasco, Daniele Saverino
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/c72fbfdb2a4141708d5861e28637b799
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