Unique subgingival microbiota associated with periodontitis in cirrhosis patients

Abstract Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodo...

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Autores principales:	Anders Jensen, Lea Ladegaard Grønkjær, Palle Holmstrup, Hendrik Vilstrup, Mogens Kilian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c73605384336437b95baa2890768d97d
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spelling	oai:doaj.org-article:c73605384336437b95baa2890768d97d2021-12-02T11:40:25ZUnique subgingival microbiota associated with periodontitis in cirrhosis patients10.1038/s41598-018-28905-w2045-2322https://doaj.org/article/c73605384336437b95baa2890768d97d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28905-whttps://doaj.org/toc/2045-2322Abstract Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most common oral diseases in cirrhosis patients. However, no studies have investigated the composition of the subgingival microbiome in patients suffering from periodontitis and liver cirrhosis. We analysed the subgingival microbiome in 21 patients with periodontitis and cirrhosis using long-reads Illumina sequencing. The subgingival microbiota was dominated by bacteria belonging to the Firmicutes phylum and to a lesser extend the Actinobacteria and Bacteroidetes phyla. Bacteria usually considered periodontal pathogens, like Porhyromonas ginigivalis, Tannerella forsythia, Treponema denticola, generally showed low abundancy. Comparing the microbiota in our patients with that of periodontitis patients and healthy controls of three other studies revealed that the periodontitis-associated subgingival microbiota in cirrhosis patients is composed of a unique microbiota of bacteria not normally associated with periodontitis. We hypothesise that periodontitis in cirrhosis patients is a consequence of dysbiosis due to a compromised immune system that renders commensal bacteria pathogenic.Anders JensenLea Ladegaard GrønkjærPalle HolmstrupHendrik VilstrupMogens KilianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anders Jensen Lea Ladegaard Grønkjær Palle Holmstrup Hendrik Vilstrup Mogens Kilian Unique subgingival microbiota associated with periodontitis in cirrhosis patients
description	Abstract Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most common oral diseases in cirrhosis patients. However, no studies have investigated the composition of the subgingival microbiome in patients suffering from periodontitis and liver cirrhosis. We analysed the subgingival microbiome in 21 patients with periodontitis and cirrhosis using long-reads Illumina sequencing. The subgingival microbiota was dominated by bacteria belonging to the Firmicutes phylum and to a lesser extend the Actinobacteria and Bacteroidetes phyla. Bacteria usually considered periodontal pathogens, like Porhyromonas ginigivalis, Tannerella forsythia, Treponema denticola, generally showed low abundancy. Comparing the microbiota in our patients with that of periodontitis patients and healthy controls of three other studies revealed that the periodontitis-associated subgingival microbiota in cirrhosis patients is composed of a unique microbiota of bacteria not normally associated with periodontitis. We hypothesise that periodontitis in cirrhosis patients is a consequence of dysbiosis due to a compromised immune system that renders commensal bacteria pathogenic.
format	article
author	Anders Jensen Lea Ladegaard Grønkjær Palle Holmstrup Hendrik Vilstrup Mogens Kilian
author_facet	Anders Jensen Lea Ladegaard Grønkjær Palle Holmstrup Hendrik Vilstrup Mogens Kilian
author_sort	Anders Jensen
title	Unique subgingival microbiota associated with periodontitis in cirrhosis patients
title_short	Unique subgingival microbiota associated with periodontitis in cirrhosis patients
title_full	Unique subgingival microbiota associated with periodontitis in cirrhosis patients
title_fullStr	Unique subgingival microbiota associated with periodontitis in cirrhosis patients
title_full_unstemmed	Unique subgingival microbiota associated with periodontitis in cirrhosis patients
title_sort	unique subgingival microbiota associated with periodontitis in cirrhosis patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c73605384336437b95baa2890768d97d
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Unique subgingival microbiota associated with periodontitis in cirrhosis patients

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