Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from the accumulation of white adipose tissues mainly due to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rajan Singh, Albert Barrios, Golnaz Dirakvand, Shehla Pervin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brown adipose tissue beige adipose tissue obesity cold exposure uncoupling protein-1 beta-adrenergic receptor Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c736a5ebead9405cb954ca5bfab8f8cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c736a5ebead9405cb954ca5bfab8f8cb
record_format	dspace
spelling	oai:doaj.org-article:c736a5ebead9405cb954ca5bfab8f8cb2021-11-25T17:10:34ZHuman Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues10.3390/cells101130302073-4409https://doaj.org/article/c736a5ebead9405cb954ca5bfab8f8cb2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3030https://doaj.org/toc/2073-4409Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from the accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. A variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago, and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. A substantially decreased BAT activity in individuals with obesity indicates a role for BAT in the setting of human obesity. On the other hand, BAT mass and its prevalence correlate with lower body mass index (BMI), decreased age and lower glucose levels, leading to a lower incidence of cardio-metabolic diseases. The increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. A deeper understanding of the role of BAT in human metabolic health and its interrelationship with body fat distribution and deciphering proper strategies to increase energy expenditure, by either increasing functional BAT mass or inducing white adipose browning, holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.Rajan SinghAlbert BarriosGolnaz DirakvandShehla PervinMDPI AGarticlebrown adipose tissuebeige adipose tissueobesitycold exposureuncoupling protein-1beta-adrenergic receptorBiology (General)QH301-705.5ENCells, Vol 10, Iss 3030, p 3030 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brown adipose tissue beige adipose tissue obesity cold exposure uncoupling protein-1 beta-adrenergic receptor Biology (General) QH301-705.5
spellingShingle	brown adipose tissue beige adipose tissue obesity cold exposure uncoupling protein-1 beta-adrenergic receptor Biology (General) QH301-705.5 Rajan Singh Albert Barrios Golnaz Dirakvand Shehla Pervin Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
description	Obesity-associated metabolic abnormalities comprise a cluster of conditions including dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from the accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. A variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago, and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. A substantially decreased BAT activity in individuals with obesity indicates a role for BAT in the setting of human obesity. On the other hand, BAT mass and its prevalence correlate with lower body mass index (BMI), decreased age and lower glucose levels, leading to a lower incidence of cardio-metabolic diseases. The increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. A deeper understanding of the role of BAT in human metabolic health and its interrelationship with body fat distribution and deciphering proper strategies to increase energy expenditure, by either increasing functional BAT mass or inducing white adipose browning, holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.
format	article
author	Rajan Singh Albert Barrios Golnaz Dirakvand Shehla Pervin
author_facet	Rajan Singh Albert Barrios Golnaz Dirakvand Shehla Pervin
author_sort	Rajan Singh
title	Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
title_short	Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
title_full	Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
title_fullStr	Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
title_full_unstemmed	Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
title_sort	human brown adipose tissue and metabolic health: potential for therapeutic avenues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c736a5ebead9405cb954ca5bfab8f8cb
work_keys_str_mv	AT rajansingh humanbrownadiposetissueandmetabolichealthpotentialfortherapeuticavenues AT albertbarrios humanbrownadiposetissueandmetabolichealthpotentialfortherapeuticavenues AT golnazdirakvand humanbrownadiposetissueandmetabolichealthpotentialfortherapeuticavenues AT shehlapervin humanbrownadiposetissueandmetabolichealthpotentialfortherapeuticavenues
_version_	1718412677330501632

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Ejemplares similares