Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery

Sarika Sabnis,1 Nirupama A Sabnis,1 Sangram Raut,2 Andras G Lacko1,3 1Institute of Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, 2Department of Physics, Texas Christian University, 3Department of Pediatrics, University of North Texas Health Science Center,...

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Autores principales:	Sabnis S, Sabnis NA, Raut S, Lacko AG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	drug delivery nanoparticles rHDL magnetic nanoparticles SPION Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c738d51fdf884dc0be3553ad70e4038b
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spelling	oai:doaj.org-article:c738d51fdf884dc0be3553ad70e4038b2021-12-02T00:31:22ZSuperparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery1178-2013https://doaj.org/article/c738d51fdf884dc0be3553ad70e4038b2017-02-01T00:00:00Zhttps://www.dovepress.com/superparamagnetic-reconstituted-high-density-lipoprotein--nanocarriers-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sarika Sabnis,1 Nirupama A Sabnis,1 Sangram Raut,2 Andras G Lacko1,3 1Institute of Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, 2Department of Physics, Texas Christian University, 3Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: Current cancer chemotherapy is frequently associated with short- and long-term side effects, affecting the quality of life of cancer survivors. Because malignant cells are known to overexpress specific surface antigens, including receptors, targeted drug delivery is often utilized to reduce or overcome side effects. The current study involves a novel targeting approach using specifically designed nanoparticles, including encapsulation of the anti-cancer drug valrubicin into superparamagnetic iron oxide nanoparticle (SPION) containing reconstituted high-density lipoprotein (rHDL) nanoparticles. Specifically, rHDL–SPION–valrubicin hybrid nanoparticles were assembled and characterized with respect to their physical and chemical properties, drug entrapment efficiency and receptor-mediated release of the drug valrubicin from the nanoparticles to prostate cancer (PC-3) cells. Prussian blue staining was used to assess nanoparticle movement in a magnetic field. Measurements of cytotoxicity toward PC-3 cells showed that rHDL–SPION–valrubicin nanoparticles were up to 4.6 and 31 times more effective at the respective valrubicin concentrations of 42.4 µg/mL and 85 µg/mL than the drug valrubicin alone. These studies showed, for the first time, that lipoprotein drug delivery enhanced via magnetic targeting could be an effective chemotherapeutic strategy for prostate cancer. Keywords: drug delivery, nanoparticles, rHDL, magnetic nanoparticles, SPIONSabnis SSabnis NARaut SLacko AGDove Medical Pressarticledrug deliverynanoparticlesrHDLmagnetic nanoparticlesSPIONMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1453-1464 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery nanoparticles rHDL magnetic nanoparticles SPION Medicine (General) R5-920
spellingShingle	drug delivery nanoparticles rHDL magnetic nanoparticles SPION Medicine (General) R5-920 Sabnis S Sabnis NA Raut S Lacko AG Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
description	Sarika Sabnis,1 Nirupama A Sabnis,1 Sangram Raut,2 Andras G Lacko1,3 1Institute of Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, 2Department of Physics, Texas Christian University, 3Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA Abstract: Current cancer chemotherapy is frequently associated with short- and long-term side effects, affecting the quality of life of cancer survivors. Because malignant cells are known to overexpress specific surface antigens, including receptors, targeted drug delivery is often utilized to reduce or overcome side effects. The current study involves a novel targeting approach using specifically designed nanoparticles, including encapsulation of the anti-cancer drug valrubicin into superparamagnetic iron oxide nanoparticle (SPION) containing reconstituted high-density lipoprotein (rHDL) nanoparticles. Specifically, rHDL–SPION–valrubicin hybrid nanoparticles were assembled and characterized with respect to their physical and chemical properties, drug entrapment efficiency and receptor-mediated release of the drug valrubicin from the nanoparticles to prostate cancer (PC-3) cells. Prussian blue staining was used to assess nanoparticle movement in a magnetic field. Measurements of cytotoxicity toward PC-3 cells showed that rHDL–SPION–valrubicin nanoparticles were up to 4.6 and 31 times more effective at the respective valrubicin concentrations of 42.4 µg/mL and 85 µg/mL than the drug valrubicin alone. These studies showed, for the first time, that lipoprotein drug delivery enhanced via magnetic targeting could be an effective chemotherapeutic strategy for prostate cancer. Keywords: drug delivery, nanoparticles, rHDL, magnetic nanoparticles, SPION
format	article
author	Sabnis S Sabnis NA Raut S Lacko AG
author_facet	Sabnis S Sabnis NA Raut S Lacko AG
author_sort	Sabnis S
title	Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
title_short	Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
title_full	Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
title_fullStr	Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
title_full_unstemmed	Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
title_sort	superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/c738d51fdf884dc0be3553ad70e4038b
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Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery

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