Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this,...

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Autores principales:	Suhasini Joshi, Erica DaGama Gomes, Tai Wang, Adriana Corben, Tony Taldone, Srinivasa Gandu, Chao Xu, Sahil Sharma, Salma Buddaseth, Pengrong Yan, Lon Yin L. Chan, Askan Gokce, Vinagolu K. Rajasekhar, Lisa Shrestha, Palak Panchal, Justina Almodovar, Chander S. Digwal, Anna Rodina, Swathi Merugu, NagaVaraKishore Pillarsetty, Vlad Miclea, Radu I. Peter, Wanyan Wang, Stephen D. Ginsberg, Laura Tang, Marissa Mattar, Elisa de Stanchina, Kenneth H. Yu, Maeve Lowery, Olivera Grbovic-Huezo, Eileen M. O’Reilly, Yelena Janjigian, John H. Healey, William R. Jarnagin, Peter J. Allen, Chris Sander, Hediye Erdjument-Bromage, Thomas A. Neubert, Steven D. Leach, Gabriela Chiosis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c73d69998238486ba39d6f85c901b64d
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spelling	oai:doaj.org-article:c73d69998238486ba39d6f85c901b64d2021-11-28T12:10:11ZPharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer10.1038/s42003-021-02842-32399-3642https://doaj.org/article/c73d69998238486ba39d6f85c901b64d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02842-3https://doaj.org/toc/2399-3642Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.Suhasini JoshiErica DaGama GomesTai WangAdriana CorbenTony TaldoneSrinivasa GanduChao XuSahil SharmaSalma BuddasethPengrong YanLon Yin L. ChanAskan GokceVinagolu K. RajasekharLisa ShresthaPalak PanchalJustina AlmodovarChander S. DigwalAnna RodinaSwathi MeruguNagaVaraKishore PillarsettyVlad MicleaRadu I. PeterWanyan WangStephen D. GinsbergLaura TangMarissa MattarElisa de StanchinaKenneth H. YuMaeve LoweryOlivera Grbovic-HuezoEileen M. O’ReillyYelena JanjigianJohn H. HealeyWilliam R. JarnaginPeter J. AllenChris SanderHediye Erdjument-BromageThomas A. NeubertSteven D. LeachGabriela ChiosisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Suhasini Joshi Erica DaGama Gomes Tai Wang Adriana Corben Tony Taldone Srinivasa Gandu Chao Xu Sahil Sharma Salma Buddaseth Pengrong Yan Lon Yin L. Chan Askan Gokce Vinagolu K. Rajasekhar Lisa Shrestha Palak Panchal Justina Almodovar Chander S. Digwal Anna Rodina Swathi Merugu NagaVaraKishore Pillarsetty Vlad Miclea Radu I. Peter Wanyan Wang Stephen D. Ginsberg Laura Tang Marissa Mattar Elisa de Stanchina Kenneth H. Yu Maeve Lowery Olivera Grbovic-Huezo Eileen M. O’Reilly Yelena Janjigian John H. Healey William R. Jarnagin Peter J. Allen Chris Sander Hediye Erdjument-Bromage Thomas A. Neubert Steven D. Leach Gabriela Chiosis Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
description	Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAPK-pathways and PI3K-mTOR pathway. To achieve this, the authors employ chemical modulation of the interactome via epichaperome inhibition with the small molecule PU-H71.
format	article
author	Suhasini Joshi Erica DaGama Gomes Tai Wang Adriana Corben Tony Taldone Srinivasa Gandu Chao Xu Sahil Sharma Salma Buddaseth Pengrong Yan Lon Yin L. Chan Askan Gokce Vinagolu K. Rajasekhar Lisa Shrestha Palak Panchal Justina Almodovar Chander S. Digwal Anna Rodina Swathi Merugu NagaVaraKishore Pillarsetty Vlad Miclea Radu I. Peter Wanyan Wang Stephen D. Ginsberg Laura Tang Marissa Mattar Elisa de Stanchina Kenneth H. Yu Maeve Lowery Olivera Grbovic-Huezo Eileen M. O’Reilly Yelena Janjigian John H. Healey William R. Jarnagin Peter J. Allen Chris Sander Hediye Erdjument-Bromage Thomas A. Neubert Steven D. Leach Gabriela Chiosis
author_facet	Suhasini Joshi Erica DaGama Gomes Tai Wang Adriana Corben Tony Taldone Srinivasa Gandu Chao Xu Sahil Sharma Salma Buddaseth Pengrong Yan Lon Yin L. Chan Askan Gokce Vinagolu K. Rajasekhar Lisa Shrestha Palak Panchal Justina Almodovar Chander S. Digwal Anna Rodina Swathi Merugu NagaVaraKishore Pillarsetty Vlad Miclea Radu I. Peter Wanyan Wang Stephen D. Ginsberg Laura Tang Marissa Mattar Elisa de Stanchina Kenneth H. Yu Maeve Lowery Olivera Grbovic-Huezo Eileen M. O’Reilly Yelena Janjigian John H. Healey William R. Jarnagin Peter J. Allen Chris Sander Hediye Erdjument-Bromage Thomas A. Neubert Steven D. Leach Gabriela Chiosis
author_sort	Suhasini Joshi
title	Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
title_short	Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
title_full	Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
title_fullStr	Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
title_full_unstemmed	Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
title_sort	pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c73d69998238486ba39d6f85c901b64d
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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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