Hepatotoxicity induced by clozapine: a case report and review of literature

Ana Isabel Wu Chou,1 Mong-Liang Lu,1,2 Winston W Shen1,2 1Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, 2Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Abstract: Clozapine is an effective antipsychotic drug but is associated with...

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Autores principales:	Wu Chou AI, Lu ML, Shen WW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c74050d9ee744144bac52edb16d2243c
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spelling	oai:doaj.org-article:c74050d9ee744144bac52edb16d2243c2021-12-02T05:38:52ZHepatotoxicity induced by clozapine: a case report and review of literature1178-2021https://doaj.org/article/c74050d9ee744144bac52edb16d2243c2014-08-01T00:00:00Zhttp://www.dovepress.com/hepatotoxicity-induced-by-clozapine-a-case-report-and-review-of-litera-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ana Isabel Wu Chou,1 Mong-Liang Lu,1,2 Winston W Shen1,2 1Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, 2Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Abstract: Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two to three times greater than normal. Though elevations in liver function tests are often transient and asymptomatic, there are many reported cases of clozapine-induced hepatotoxicity, with damage to the liver, involvement of multiple organs, and even fulminant liver failure arising with moderate clozapine doses. This case report describes a Chinese woman who developed hepatotoxicity on a low dose of clozapine, and reviews the relevant literature. Keywords: hepatitis, antipsychotic adverse effects, drug-induced liver injuryWu Chou AILu MLShen WWDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1585-1587 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wu Chou AI Lu ML Shen WW Hepatotoxicity induced by clozapine: a case report and review of literature
description	Ana Isabel Wu Chou,1 Mong-Liang Lu,1,2 Winston W Shen1,2 1Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, 2Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan Abstract: Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two to three times greater than normal. Though elevations in liver function tests are often transient and asymptomatic, there are many reported cases of clozapine-induced hepatotoxicity, with damage to the liver, involvement of multiple organs, and even fulminant liver failure arising with moderate clozapine doses. This case report describes a Chinese woman who developed hepatotoxicity on a low dose of clozapine, and reviews the relevant literature. Keywords: hepatitis, antipsychotic adverse effects, drug-induced liver injury
format	article
author	Wu Chou AI Lu ML Shen WW
author_facet	Wu Chou AI Lu ML Shen WW
author_sort	Wu Chou AI
title	Hepatotoxicity induced by clozapine: a case report and review of literature
title_short	Hepatotoxicity induced by clozapine: a case report and review of literature
title_full	Hepatotoxicity induced by clozapine: a case report and review of literature
title_fullStr	Hepatotoxicity induced by clozapine: a case report and review of literature
title_full_unstemmed	Hepatotoxicity induced by clozapine: a case report and review of literature
title_sort	hepatotoxicity induced by clozapine: a case report and review of literature
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/c74050d9ee744144bac52edb16d2243c
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_version_	1718400321202421760

Hepatotoxicity induced by clozapine: a case report and review of literature

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