Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease

Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease

Mitochondrial dysfunction is a common hallmark of neurological disorders. Here, the authors identify CHIR99021 as a potent enhancer of mitochondrial function, which improved mitochondrial phenotypes in Huntington’s disease models. CHIR99021 was shown to stabilize calpastatin, which suppressed calpai...

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Autores principales: Di Hu, Xiaoyan Sun, Anniefer Magpusao, Yuriy Fedorov, Matthew Thompson, Benlian Wang, Kathleen Lundberg, Drew J. Adams, Xin Qi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c744060975464ee4847cf813f125987b
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