Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers

To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older me...

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Autores principales:	Andreas Nilsson, Antonio Cano, Oscar Bergens, Fawzi Kadi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fruit and vegetables inflammation diet nutrition physical activity aging Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c745fd25d4a14447b13aca65638fa2f0
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spelling	oai:doaj.org-article:c745fd25d4a14447b13aca65638fa2f02021-11-25T18:33:46ZRandomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers10.3390/nu131137532072-6643https://doaj.org/article/c745fd25d4a14447b13aca65638fa2f02021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3753https://doaj.org/toc/2072-6643To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older men and women. Sixty-six participants (65–70 years) randomly assigned to either FV or control (CON) groups were instructed to increase FV intake to five servings per day through nutritional counseling (FV) or to maintain habitual diet (CON). Dietary intake and physical activity level (PA) were determined using food frequency questionnaire and accelerometers, respectively, at the start and end of the intervention. C-reactive protein (CRP), interleukin 6 (IL-6), IL-18, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, tumor necrosis factor-α (TNF-α), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related activation-induced cytokine (TRANCE), and C-X3-C motif chemokine ligand-1 (CX3CL1, or fractalkine) were analyzed. The FV group significantly increased daily FV intake (from 2.2 ± 1.3 to 4.2 ± 1.8 servings/day), with no change in CON. Waist circumference and PA level were unchanged by the intervention. Interaction effects (time × group, <i>p</i> < 0.05) for TRAIL, TRANCE, and CX3CL1 denoting a significant decrease (<i>p</i> < 0.05) in FV but not in CON were observed. No corresponding effects on CRP, IL6, TNF-α, MIP-1α, and β and IL-18 were observed. The present study demonstrates the influence of increased FV consumption on levels of some inflammatory biomarkers in a population of older adults. Future work is warranted to examine the clinical implications of FV-induced alterations in these inflammatory biomarkers.Andreas NilssonAntonio CanoOscar BergensFawzi KadiMDPI AGarticlefruit and vegetablesinflammationdietnutritionphysical activityagingNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3753, p 3753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fruit and vegetables inflammation diet nutrition physical activity aging Nutrition. Foods and food supply TX341-641
spellingShingle	fruit and vegetables inflammation diet nutrition physical activity aging Nutrition. Foods and food supply TX341-641 Andreas Nilsson Antonio Cano Oscar Bergens Fawzi Kadi Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
description	To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older men and women. Sixty-six participants (65–70 years) randomly assigned to either FV or control (CON) groups were instructed to increase FV intake to five servings per day through nutritional counseling (FV) or to maintain habitual diet (CON). Dietary intake and physical activity level (PA) were determined using food frequency questionnaire and accelerometers, respectively, at the start and end of the intervention. C-reactive protein (CRP), interleukin 6 (IL-6), IL-18, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, tumor necrosis factor-α (TNF-α), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related activation-induced cytokine (TRANCE), and C-X3-C motif chemokine ligand-1 (CX3CL1, or fractalkine) were analyzed. The FV group significantly increased daily FV intake (from 2.2 ± 1.3 to 4.2 ± 1.8 servings/day), with no change in CON. Waist circumference and PA level were unchanged by the intervention. Interaction effects (time × group, <i>p</i> < 0.05) for TRAIL, TRANCE, and CX3CL1 denoting a significant decrease (<i>p</i> < 0.05) in FV but not in CON were observed. No corresponding effects on CRP, IL6, TNF-α, MIP-1α, and β and IL-18 were observed. The present study demonstrates the influence of increased FV consumption on levels of some inflammatory biomarkers in a population of older adults. Future work is warranted to examine the clinical implications of FV-induced alterations in these inflammatory biomarkers.
format	article
author	Andreas Nilsson Antonio Cano Oscar Bergens Fawzi Kadi
author_facet	Andreas Nilsson Antonio Cano Oscar Bergens Fawzi Kadi
author_sort	Andreas Nilsson
title	Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
title_short	Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
title_full	Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
title_fullStr	Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
title_full_unstemmed	Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers
title_sort	randomized controlled trial for promotion of healthy eating in older adults by increasing consumption of plant-based foods: effect on inflammatory biomarkers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c745fd25d4a14447b13aca65638fa2f0
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Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers

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