The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin.
The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genom...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c7467c0c5789430e9c22854e05cacc1c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c7467c0c5789430e9c22854e05cacc1c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c7467c0c5789430e9c22854e05cacc1c2021-11-18T07:22:21ZThe crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin.1932-620310.1371/journal.pone.0034012https://doaj.org/article/c7467c0c5789430e9c22854e05cacc1c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22514613/?tool=EBIhttps://doaj.org/toc/1932-6203The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in cranial skin during embryonic development. We propose that Crest is caused by a cis-acting regulatory mutation underlying the ectopic expression of HOXC8. However, the identification of the causative mutation(s) has to await until a method becomes available for assembling this chromosomal region. Crest is unfortunately located in a genomic region that has so far defied all attempts to establish a contiguous sequence.Yanqiang WangYu GaoFreyja ImslandXiaorong GuChungang FengRanran LiuChi SongMichèle Tixier-BoichardDavid GourichonQingyuan LiKuanwei ChenHuifang LiLeif AnderssonXiaoxiang HuNing LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34012 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yanqiang Wang Yu Gao Freyja Imsland Xiaorong Gu Chungang Feng Ranran Liu Chi Song Michèle Tixier-Boichard David Gourichon Qingyuan Li Kuanwei Chen Huifang Li Leif Andersson Xiaoxiang Hu Ning Li The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| description |
The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in cranial skin during embryonic development. We propose that Crest is caused by a cis-acting regulatory mutation underlying the ectopic expression of HOXC8. However, the identification of the causative mutation(s) has to await until a method becomes available for assembling this chromosomal region. Crest is unfortunately located in a genomic region that has so far defied all attempts to establish a contiguous sequence. |
| format |
article |
| author |
Yanqiang Wang Yu Gao Freyja Imsland Xiaorong Gu Chungang Feng Ranran Liu Chi Song Michèle Tixier-Boichard David Gourichon Qingyuan Li Kuanwei Chen Huifang Li Leif Andersson Xiaoxiang Hu Ning Li |
| author_facet |
Yanqiang Wang Yu Gao Freyja Imsland Xiaorong Gu Chungang Feng Ranran Liu Chi Song Michèle Tixier-Boichard David Gourichon Qingyuan Li Kuanwei Chen Huifang Li Leif Andersson Xiaoxiang Hu Ning Li |
| author_sort |
Yanqiang Wang |
| title |
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| title_short |
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| title_full |
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| title_fullStr |
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| title_full_unstemmed |
The crest phenotype in chicken is associated with ectopic expression of HOXC8 in cranial skin. |
| title_sort |
crest phenotype in chicken is associated with ectopic expression of hoxc8 in cranial skin. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/c7467c0c5789430e9c22854e05cacc1c |
| work_keys_str_mv |
AT yanqiangwang thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT yugao thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT freyjaimsland thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT xiaoronggu thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT chungangfeng thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT ranranliu thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT chisong thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT micheletixierboichard thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT davidgourichon thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT qingyuanli thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT kuanweichen thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT huifangli thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT leifandersson thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT xiaoxianghu thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT ningli thecrestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT yanqiangwang crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT yugao crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT freyjaimsland crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT xiaoronggu crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT chungangfeng crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT ranranliu crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT chisong crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT micheletixierboichard crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT davidgourichon crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT qingyuanli crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT kuanweichen crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT huifangli crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT leifandersson crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT xiaoxianghu crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin AT ningli crestphenotypeinchickenisassociatedwithectopicexpressionofhoxc8incranialskin |
| _version_ |
1718423562600054784 |