Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites

Meng-Hsuan Lin et al. investigate MERS-CoV macro domain binding selectivity with NAD and NAD metabolites under various conditions. At physiological temperature, NAD is observed to have enhanced binding affinity to the MERS-CoV macro domain, shedding light on a new possible role of the MERS-CoV macro...

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Autores principales:	Meng-Hsuan Lin, Chao-Cheng Cho, Yi-Chih Chiu, Chia-Yu Chien, Yi-Ping Huang, Chi-Fon Chang, Chun-Hua Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c746f4f54dab40188dea1673f5a05a7b
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spelling	oai:doaj.org-article:c746f4f54dab40188dea1673f5a05a7b2021-12-02T14:16:33ZElucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites10.1038/s42003-020-01633-62399-3642https://doaj.org/article/c746f4f54dab40188dea1673f5a05a7b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01633-6https://doaj.org/toc/2399-3642Meng-Hsuan Lin et al. investigate MERS-CoV macro domain binding selectivity with NAD and NAD metabolites under various conditions. At physiological temperature, NAD is observed to have enhanced binding affinity to the MERS-CoV macro domain, shedding light on a new possible role of the MERS-CoV macro domain in viral replication.Meng-Hsuan LinChao-Cheng ChoYi-Chih ChiuChia-Yu ChienYi-Ping HuangChi-Fon ChangChun-Hua HsuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Meng-Hsuan Lin Chao-Cheng Cho Yi-Chih Chiu Chia-Yu Chien Yi-Ping Huang Chi-Fon Chang Chun-Hua Hsu Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
description	Meng-Hsuan Lin et al. investigate MERS-CoV macro domain binding selectivity with NAD and NAD metabolites under various conditions. At physiological temperature, NAD is observed to have enhanced binding affinity to the MERS-CoV macro domain, shedding light on a new possible role of the MERS-CoV macro domain in viral replication.
format	article
author	Meng-Hsuan Lin Chao-Cheng Cho Yi-Chih Chiu Chia-Yu Chien Yi-Ping Huang Chi-Fon Chang Chun-Hua Hsu
author_facet	Meng-Hsuan Lin Chao-Cheng Cho Yi-Chih Chiu Chia-Yu Chien Yi-Ping Huang Chi-Fon Chang Chun-Hua Hsu
author_sort	Meng-Hsuan Lin
title	Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
title_short	Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
title_full	Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
title_fullStr	Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
title_full_unstemmed	Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
title_sort	elucidating the tunability of binding behavior for the mers-cov macro domain with nad metabolites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c746f4f54dab40188dea1673f5a05a7b
work_keys_str_mv	AT menghsuanlin elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT chaochengcho elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT yichihchiu elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT chiayuchien elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT yipinghuang elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT chifonchang elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites AT chunhuahsu elucidatingthetunabilityofbindingbehaviorforthemerscovmacrodomainwithnadmetabolites
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Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites

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