Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.

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Autores principales:	Gozde Kar, Jong Kyoung Kim, Aleksandra A. Kolodziejczyk, Kedar Nath Natarajan, Elena Torlai Triglia, Borbala Mifsud, Sarah Elderkin, John C. Marioni, Ana Pombo, Sarah A. Teichmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c747a0f3ef654e3ebe5c97e9ab3dfe7f
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spelling	oai:doaj.org-article:c747a0f3ef654e3ebe5c97e9ab3dfe7f2021-12-02T10:48:19ZFlipping between Polycomb repressed and active transcriptional states introduces noise in gene expression10.1038/s41467-017-00052-22041-1723https://doaj.org/article/c747a0f3ef654e3ebe5c97e9ab3dfe7f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00052-2https://doaj.org/toc/2041-1723Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.Gozde KarJong Kyoung KimAleksandra A. KolodziejczykKedar Nath NatarajanElena Torlai TrigliaBorbala MifsudSarah ElderkinJohn C. MarioniAna PomboSarah A. TeichmannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gozde Kar Jong Kyoung Kim Aleksandra A. Kolodziejczyk Kedar Nath Natarajan Elena Torlai Triglia Borbala Mifsud Sarah Elderkin John C. Marioni Ana Pombo Sarah A. Teichmann Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
description	Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.
format	article
author	Gozde Kar Jong Kyoung Kim Aleksandra A. Kolodziejczyk Kedar Nath Natarajan Elena Torlai Triglia Borbala Mifsud Sarah Elderkin John C. Marioni Ana Pombo Sarah A. Teichmann
author_facet	Gozde Kar Jong Kyoung Kim Aleksandra A. Kolodziejczyk Kedar Nath Natarajan Elena Torlai Triglia Borbala Mifsud Sarah Elderkin John C. Marioni Ana Pombo Sarah A. Teichmann
author_sort	Gozde Kar
title	Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
title_short	Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
title_full	Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
title_fullStr	Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
title_full_unstemmed	Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
title_sort	flipping between polycomb repressed and active transcriptional states introduces noise in gene expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c747a0f3ef654e3ebe5c97e9ab3dfe7f
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Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

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