PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD

This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: “amansamachos”). This specie is a medicinal plant used in Colombian traditional...

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Autores principales:	Sandra Y. ARIZA, Diana C. RUEDA, Javier RINCÓN V., Edgar L. LINARES, Mario F. GUERRERO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	This study shows the isolation identification and pharmacological profile on the central nervous system Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/c74b4a68626b47a8ac121688496b2324
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spelling	oai:doaj.org-article:c74b4a68626b47a8ac121688496b23242021-11-19T04:20:51ZPHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD0121-40042145-2660https://doaj.org/article/c74b4a68626b47a8ac121688496b23242009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/613https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: “amansamachos”). This specie is a medicinal plant used in Colombian traditional medicine for the treatment of anxiety. Tests destined to detect possible activity of anxiolytic type (elevated plus maze, marble burying behavior), anticonvulsant (electroshock, pentylenetetrazole), sedative (pentobarbital and ether sleep time) and miorelaxant (wiring test) were used in albino ICR mice. According to the positive results in the plus maze, marble burying, electroshock and sleep tests, coumarin (200 mg/kg, po) seems to be a key compound in the pharmacological response induced by Hygrophila tyttha. These results may led to the finding of therapeutic alternatives of anxiolytic, anticonvulsant and/or sedative kind from this natural compound. Sandra Y. ARIZADiana C. RUEDAJavier RINCÓN V.Edgar L. LINARESMario F. GUERREROUniversidad de AntioquiaarticleThis study shows the isolationidentification and pharmacological profile on the central nervous systemFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	This study shows the isolation identification and pharmacological profile on the central nervous system Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	This study shows the isolation identification and pharmacological profile on the central nervous system Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Sandra Y. ARIZA Diana C. RUEDA Javier RINCÓN V. Edgar L. LINARES Mario F. GUERRERO PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
description	This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: “amansamachos”). This specie is a medicinal plant used in Colombian traditional medicine for the treatment of anxiety. Tests destined to detect possible activity of anxiolytic type (elevated plus maze, marble burying behavior), anticonvulsant (electroshock, pentylenetetrazole), sedative (pentobarbital and ether sleep time) and miorelaxant (wiring test) were used in albino ICR mice. According to the positive results in the plus maze, marble burying, electroshock and sleep tests, coumarin (200 mg/kg, po) seems to be a key compound in the pharmacological response induced by Hygrophila tyttha. These results may led to the finding of therapeutic alternatives of anxiolytic, anticonvulsant and/or sedative kind from this natural compound.
format	article
author	Sandra Y. ARIZA Diana C. RUEDA Javier RINCÓN V. Edgar L. LINARES Mario F. GUERRERO
author_facet	Sandra Y. ARIZA Diana C. RUEDA Javier RINCÓN V. Edgar L. LINARES Mario F. GUERRERO
author_sort	Sandra Y. ARIZA
title	PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
title_short	PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
title_full	PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
title_fullStr	PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
title_full_unstemmed	PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD
title_sort	pharmacological effects on the central nervous system induced by coumarin, isolated from <i>hygrophila tyttha</i> leonard
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/c74b4a68626b47a8ac121688496b2324
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PHARMACOLOGICAL EFFECTS ON THE CENTRAL NERVOUS SYSTEM INDUCED BY COUMARIN, ISOLATED FROM <I>Hygrophila tyttha</I> LEONARD

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