Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study

Abstract In some breast cancer (BC) patients, an examination of lymph nodes dissected during sentinel lymph node biopsy (SLNB) demonstrates a presence of metastatic lesions and extracapsular extension (ECE) in a SLN. This study aimed to evaluate clinical relevance of ECE in BC patients. This is a re...

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Autores principales:	Tomasz Nowikiewicz, Andrzej Kurylcio, Iwona Głowacka-Mrotek, Maria Szymankiewicz, Magdalena Nowikiewicz, Wojciech Zegarski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c74b9483f5764041a0a694ae588ddd15
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spelling	oai:doaj.org-article:c74b9483f5764041a0a694ae588ddd152021-12-02T17:14:58ZClinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study10.1038/s41598-021-88351-z2045-2322https://doaj.org/article/c74b9483f5764041a0a694ae588ddd152021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88351-zhttps://doaj.org/toc/2045-2322Abstract In some breast cancer (BC) patients, an examination of lymph nodes dissected during sentinel lymph node biopsy (SLNB) demonstrates a presence of metastatic lesions and extracapsular extension (ECE) in a SLN. This study aimed to evaluate clinical relevance of ECE in BC patients. This is a retrospective analysis of 891 patients with cancer metastases to SLN, referred to supplementary axillary lymph node dissection (ALND), hospitalized between Jan 2007 and Dec 2017. Clinical and epidemiological data was evaluated. Long-term treatment outcomes were analysed. In 433 (48.6%) patients, cancer metastases were limited to the SLN (group I), in 61 (6.8%) patients the SLN capsule was exceeded focally (≤ 1 mm—group II). In 397 (44.6%) patients, a more extensive ECE was found (> 1 mm—group III). Metastases to non-sentinel lymph nodes (nSLNs) were diagnosed in 27.0% patients from group I, 44.3% patients from group II and in 49.6% patients from group III. No statistically significant differences were observed in long-term treatment outcomes for compared groups. The presence of ECE is accompanied by a higher stage of metastatic lesions in the lymphatic system. The differences in this respect were statistically significant, when compared to the group of ECE(−) patients. ECE, regardless of its extent, did not impact the long-term treatment results. ECE remains an indication for supplementary ALND and for other equivalent cancer treatment procedures, regardless of ECE size.Tomasz NowikiewiczAndrzej KurylcioIwona Głowacka-MrotekMaria SzymankiewiczMagdalena NowikiewiczWojciech ZegarskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomasz Nowikiewicz Andrzej Kurylcio Iwona Głowacka-Mrotek Maria Szymankiewicz Magdalena Nowikiewicz Wojciech Zegarski Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
description	Abstract In some breast cancer (BC) patients, an examination of lymph nodes dissected during sentinel lymph node biopsy (SLNB) demonstrates a presence of metastatic lesions and extracapsular extension (ECE) in a SLN. This study aimed to evaluate clinical relevance of ECE in BC patients. This is a retrospective analysis of 891 patients with cancer metastases to SLN, referred to supplementary axillary lymph node dissection (ALND), hospitalized between Jan 2007 and Dec 2017. Clinical and epidemiological data was evaluated. Long-term treatment outcomes were analysed. In 433 (48.6%) patients, cancer metastases were limited to the SLN (group I), in 61 (6.8%) patients the SLN capsule was exceeded focally (≤ 1 mm—group II). In 397 (44.6%) patients, a more extensive ECE was found (> 1 mm—group III). Metastases to non-sentinel lymph nodes (nSLNs) were diagnosed in 27.0% patients from group I, 44.3% patients from group II and in 49.6% patients from group III. No statistically significant differences were observed in long-term treatment outcomes for compared groups. The presence of ECE is accompanied by a higher stage of metastatic lesions in the lymphatic system. The differences in this respect were statistically significant, when compared to the group of ECE(−) patients. ECE, regardless of its extent, did not impact the long-term treatment results. ECE remains an indication for supplementary ALND and for other equivalent cancer treatment procedures, regardless of ECE size.
format	article
author	Tomasz Nowikiewicz Andrzej Kurylcio Iwona Głowacka-Mrotek Maria Szymankiewicz Magdalena Nowikiewicz Wojciech Zegarski
author_facet	Tomasz Nowikiewicz Andrzej Kurylcio Iwona Głowacka-Mrotek Maria Szymankiewicz Magdalena Nowikiewicz Wojciech Zegarski
author_sort	Tomasz Nowikiewicz
title	Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
title_short	Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
title_full	Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
title_fullStr	Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
title_full_unstemmed	Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
title_sort	clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c74b9483f5764041a0a694ae588ddd15
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Clinical relevance of a degree of extracapsular extension in a sentinel lymph node in breast cancer patients: a single-centre study

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