Bilateral ptosis/blepharitis due to lepromatous leprosy

Purpose: To underscore the importance of histopathological evaluation in cases presenting with a constellation of unusual ocular inflammation and physical findings. Observation: A 51-year-old male, presented with a chief complaint of worsening visual field loss due to droopy eyelids two months post...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Omar Iqbal, Marlyn P. Langford, Ashley B. Flowers, James L. Caldwell, Nicolas A. Zaunbrecher, William A. Byrd
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Acid-fast bacillus Eye Hansen's disease Mycobacterium leprae Neuropathy Pancytopenia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c74d580be8be42f5abfd7442b61c508a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c74d580be8be42f5abfd7442b61c508a
record_format	dspace
spelling	oai:doaj.org-article:c74d580be8be42f5abfd7442b61c508a2021-12-04T04:35:28ZBilateral ptosis/blepharitis due to lepromatous leprosy2451-993610.1016/j.ajoc.2021.101236https://doaj.org/article/c74d580be8be42f5abfd7442b61c508a2022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2451993621002450https://doaj.org/toc/2451-9936Purpose: To underscore the importance of histopathological evaluation in cases presenting with a constellation of unusual ocular inflammation and physical findings. Observation: A 51-year-old male, presented with a chief complaint of worsening visual field loss due to droopy eyelids two months post excision of a right upper eyelid squamous cell carcinoma. His past medical history included chronic edematous facial features, chronic sinusitis, unexplained peripheral neuropathy, and worsening fatigue. Pre-blepharoplasty work-up revealed mechanical ptosis from lid edema, madarosis, a concave nasal bridge, pancytopenia, and numerous burn marks due to inadvertent injuries. Bilateral blepharoplasty was performed, and the excised tissue submitted for histopathological evaluation that revealed non-caseating granulomatous perineural inflammation with numerous acid-fast bacilli in dermal layers and nerves. These findings prompted a diagnosis of lepromatous leprosy with suspected bone marrow involvement. The source of the infection was unknown. The blepharoplasty restored his visual fields and multi-drug therapy (MDT) improved his general health and wellbeing with concomitant reductions of pancytopenia, fatigue, and facial edema. Conclusions and importance: Biopsy histopathology, in patients with longstanding ocular adnexal inflammation, can facilitate diagnosis and treatment. To the authors’ knowledge, this is an unusual ocular leprosy presentation and represents the first leprosy case diagnosed via blepharoplasty.Omar IqbalMarlyn P. LangfordAshley B. FlowersJames L. CaldwellNicolas A. ZaunbrecherWilliam A. ByrdElsevierarticleAcid-fast bacillusEyeHansen's diseaseMycobacterium lepraeNeuropathyPancytopeniaOphthalmologyRE1-994ENAmerican Journal of Ophthalmology Case Reports, Vol 25, Iss , Pp 101236- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acid-fast bacillus Eye Hansen's disease Mycobacterium leprae Neuropathy Pancytopenia Ophthalmology RE1-994
spellingShingle	Acid-fast bacillus Eye Hansen's disease Mycobacterium leprae Neuropathy Pancytopenia Ophthalmology RE1-994 Omar Iqbal Marlyn P. Langford Ashley B. Flowers James L. Caldwell Nicolas A. Zaunbrecher William A. Byrd Bilateral ptosis/blepharitis due to lepromatous leprosy
description	Purpose: To underscore the importance of histopathological evaluation in cases presenting with a constellation of unusual ocular inflammation and physical findings. Observation: A 51-year-old male, presented with a chief complaint of worsening visual field loss due to droopy eyelids two months post excision of a right upper eyelid squamous cell carcinoma. His past medical history included chronic edematous facial features, chronic sinusitis, unexplained peripheral neuropathy, and worsening fatigue. Pre-blepharoplasty work-up revealed mechanical ptosis from lid edema, madarosis, a concave nasal bridge, pancytopenia, and numerous burn marks due to inadvertent injuries. Bilateral blepharoplasty was performed, and the excised tissue submitted for histopathological evaluation that revealed non-caseating granulomatous perineural inflammation with numerous acid-fast bacilli in dermal layers and nerves. These findings prompted a diagnosis of lepromatous leprosy with suspected bone marrow involvement. The source of the infection was unknown. The blepharoplasty restored his visual fields and multi-drug therapy (MDT) improved his general health and wellbeing with concomitant reductions of pancytopenia, fatigue, and facial edema. Conclusions and importance: Biopsy histopathology, in patients with longstanding ocular adnexal inflammation, can facilitate diagnosis and treatment. To the authors’ knowledge, this is an unusual ocular leprosy presentation and represents the first leprosy case diagnosed via blepharoplasty.
format	article
author	Omar Iqbal Marlyn P. Langford Ashley B. Flowers James L. Caldwell Nicolas A. Zaunbrecher William A. Byrd
author_facet	Omar Iqbal Marlyn P. Langford Ashley B. Flowers James L. Caldwell Nicolas A. Zaunbrecher William A. Byrd
author_sort	Omar Iqbal
title	Bilateral ptosis/blepharitis due to lepromatous leprosy
title_short	Bilateral ptosis/blepharitis due to lepromatous leprosy
title_full	Bilateral ptosis/blepharitis due to lepromatous leprosy
title_fullStr	Bilateral ptosis/blepharitis due to lepromatous leprosy
title_full_unstemmed	Bilateral ptosis/blepharitis due to lepromatous leprosy
title_sort	bilateral ptosis/blepharitis due to lepromatous leprosy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c74d580be8be42f5abfd7442b61c508a
work_keys_str_mv	AT omariqbal bilateralptosisblepharitisduetolepromatousleprosy AT marlynplangford bilateralptosisblepharitisduetolepromatousleprosy AT ashleybflowers bilateralptosisblepharitisduetolepromatousleprosy AT jameslcaldwell bilateralptosisblepharitisduetolepromatousleprosy AT nicolasazaunbrecher bilateralptosisblepharitisduetolepromatousleprosy AT williamabyrd bilateralptosisblepharitisduetolepromatousleprosy
_version_	1718372939505598464

Bilateral ptosis/blepharitis due to lepromatous leprosy

Ejemplares similares