A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

Paclitaxel, a first line chemotherapeutic drug, suffers from poor water solubility and low tissue selectivity. Here, the authors report a water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profil...

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Autores principales: Fangfei Li, Jun Lu, Jin Liu, Chao Liang, Maolin Wang, Luyao Wang, Defang Li, Houzong Yao, Qiulong Zhang, Jia Wen, Zong-Kang Zhang, Jie Li, Quanxia Lv, Xiaojuan He, Baosheng Guo, Daogang Guan, Yuanyuan Yu, Lei Dang, Xiaohao Wu, Yongshu Li, Guofen Chen, Feng Jiang, Shiguo Sun, Bao-Ting Zhang, Aiping Lu, Ge Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c74e34d161c444469af0643c90b25955
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spelling oai:doaj.org-article:c74e34d161c444469af0643c90b259552021-12-02T17:06:27ZA water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer10.1038/s41467-017-01565-62041-1723https://doaj.org/article/c74e34d161c444469af0643c90b259552017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01565-6https://doaj.org/toc/2041-1723Paclitaxel, a first line chemotherapeutic drug, suffers from poor water solubility and low tissue selectivity. Here, the authors report a water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profiles.Fangfei LiJun LuJin LiuChao LiangMaolin WangLuyao WangDefang LiHouzong YaoQiulong ZhangJia WenZong-Kang ZhangJie LiQuanxia LvXiaojuan HeBaosheng GuoDaogang GuanYuanyuan YuLei DangXiaohao WuYongshu LiGuofen ChenFeng JiangShiguo SunBao-Ting ZhangAiping LuGe ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fangfei Li
Jun Lu
Jin Liu
Chao Liang
Maolin Wang
Luyao Wang
Defang Li
Houzong Yao
Qiulong Zhang
Jia Wen
Zong-Kang Zhang
Jie Li
Quanxia Lv
Xiaojuan He
Baosheng Guo
Daogang Guan
Yuanyuan Yu
Lei Dang
Xiaohao Wu
Yongshu Li
Guofen Chen
Feng Jiang
Shiguo Sun
Bao-Ting Zhang
Aiping Lu
Ge Zhang
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
description Paclitaxel, a first line chemotherapeutic drug, suffers from poor water solubility and low tissue selectivity. Here, the authors report a water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profiles.
format article
author Fangfei Li
Jun Lu
Jin Liu
Chao Liang
Maolin Wang
Luyao Wang
Defang Li
Houzong Yao
Qiulong Zhang
Jia Wen
Zong-Kang Zhang
Jie Li
Quanxia Lv
Xiaojuan He
Baosheng Guo
Daogang Guan
Yuanyuan Yu
Lei Dang
Xiaohao Wu
Yongshu Li
Guofen Chen
Feng Jiang
Shiguo Sun
Bao-Ting Zhang
Aiping Lu
Ge Zhang
author_facet Fangfei Li
Jun Lu
Jin Liu
Chao Liang
Maolin Wang
Luyao Wang
Defang Li
Houzong Yao
Qiulong Zhang
Jia Wen
Zong-Kang Zhang
Jie Li
Quanxia Lv
Xiaojuan He
Baosheng Guo
Daogang Guan
Yuanyuan Yu
Lei Dang
Xiaohao Wu
Yongshu Li
Guofen Chen
Feng Jiang
Shiguo Sun
Bao-Ting Zhang
Aiping Lu
Ge Zhang
author_sort Fangfei Li
title A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
title_short A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
title_full A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
title_fullStr A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
title_full_unstemmed A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
title_sort water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c74e34d161c444469af0643c90b25955
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